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Molecular Biology

, Volume 53, Issue 2, pp 192–197 | Cite as

Prokaryotic and Mitochondrial Linear Genomes: Their Genesis, Evolutionary Significance, and the Problem of Replicating Chromosome Ends

  • M. A. MoldovanEmail author
REVIEWS

Abstract—

Bacterial chromosomes are widely thought of as circular DNA molecules. However, linear bacterial chromosomes, as well as linear mitochondrial and plastid chromosomes, are fairly common. The most frequent causes of linearization are reparation system defects, incorporation of plasmids in the genome, and recombination compromising the circular topology of chromosomes. Genomes of some bacterial species had undergone frequent linearization–circularization events, which resulted in an increased variability of gene content at linear chromosome ends. Similarly to eukaryotes, bacteria that have linear genomes face the problem of end replication, which different species solve in a variety of ways. A theoretically important issue is the adaptive value of chromosome linearization. This review discusses theories concerning the evolution of linear genomes and supporting experiments. The most common mechanisms of linear bacterial genomes replication and possible ways of their emergence are also considered.

Keywords:

linear genomes prokaryotic chromosome chromosome topology mitochondrial chromosome genome linearization ends replication 

Notes

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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  1. 1.Kharkevich Institute for Information Transmission Problems, Russian Academy of SciencesMoscowRussia
  2. 2.Department of Bioengineering and Bioinformatics, Moscow State UniversityMoscowRussia
  3. 3.Skolkovo Institute for Science and TechnologyMoscowRussia

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