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Molecular Biology

, Volume 52, Issue 6, pp 846–853 | Cite as

The Common Partner of Several Methyltransferases Modifying the Components of The Eukaryotic Translation Apparatus

  • E. N. VasilievaEmail author
  • I. G. Laptev
  • P. V. Sergiev
  • O. A. Dontsova
REVIEWS
  • 44 Downloads

Abstract

TRM112 is necessary for the activation and stability of several methyltransferases involved in the modification of various components of the translation apparatus. This unique protein is a partner for enzymes that methylate tRNA, rRNA, and the translation termination factor. Here we review the structural and functional features of the TRM112 complexes with methyltransferases and provide, where possible, information on their significance.

Keywords:

methylation translation methyltransferase tRNA rRNA translation termination factor ribosome assembly 

Notes

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • E. N. Vasilieva
    • 1
    Email author
  • I. G. Laptev
    • 2
    • 3
  • P. V. Sergiev
    • 2
    • 3
  • O. A. Dontsova
    • 2
    • 3
    • 4
  1. 1.Faculty of Bioengineering and Bioinformatics, Moscow State UniversityMoscowRussia
  2. 2.Faculty of Chemistry, Moscow State UniversityMoscowRussia
  3. 3.Skolkovo Institute of Science and TechnologySkolkovoRussia
  4. 4.Shemyakin–Ovchinnikov Institute of Bioorganic ChemistryMoscowRussia

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