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Molecular Biology

, Volume 51, Issue 6, pp 921–926 | Cite as

Humanization of Murine Monoclonal anti-hTNF Antibody: The F10 Story

  • G. A. Efimov
  • J. M. H. Raats
  • R. G. S. Chirivi
  • J. W. G. van Rosmalen
  • S. A. Nedospasov
Current Trends in the Application of Monoclonal Antibodies Special Issue
  • 40 Downloads

Abstract

Tumor necrosis factor (TNF) is a proinflammatory cytokine implicated in pathogenesis of multiple autoimmune and inflammatory diseases. Anti-TNF therapy has revolutionized the therapeutic paradigms of autoimmune diseases and became one of the most successful examples of the clinical use of monoclonal antibodies. Currently, anti-TNF therapy is used by millions of patients worldwide. At the moment, fully human anti-TNF antibody Adalimumab is the best-selling anti-cytokine drug in the world. Here, we present a story about a highly potent anti-TNF monoclonal antibody initially characterized more than 20 years ago and further developed into chimeric and humanized versions. We present comparative analysis of this antibody with Infliximab and Adalimumab.

Keywords

TNF tumor necrosis factor recombinant antibodies humanized antibodies 

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Copyright information

© Pleiades Publishing, Inc. 2017

Authors and Affiliations

  • G. A. Efimov
    • 1
    • 2
    • 3
  • J. M. H. Raats
    • 4
  • R. G. S. Chirivi
    • 4
  • J. W. G. van Rosmalen
    • 4
  • S. A. Nedospasov
    • 2
    • 3
    • 5
  1. 1.National Research Center for HematologyMinistry of Healthcare of the Russian FederationMoscowRussia
  2. 2.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia
  3. 3.Moscow State UniversityMoscowRussia
  4. 4.ModiQuest B.V.AE OssThe Netherlands
  5. 5.Lobachevsky University of Nizhny NovgorodNizhny NovgorodRussia

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