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Molecular Biology

, Volume 52, Issue 2, pp 182–189 | Cite as

Role of the Nucleolus in Rearrangements of the IGH Locus

  • O. V. Iarovaia
  • E. S. Ioudinkova
  • S. V. Razin
  • Y. S. Vassetzky
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Abstract

The review summarizes the results from a series of studies focusing on the role that the nucleolus plays in maturation of the IGH locus and the choice of its partner genes in leukemia-associated translocations. The role of nuclear compartmentalization and nuclear localization of translocated oncogenes in ectopic activation of their transcription is discussed.

Keywords

compartmentalization of the nucleus spatial organization of the genome IGH locus leukemiaassociated translocations 
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© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • O. V. Iarovaia
    • 1
    • 2
    • 4
  • E. S. Ioudinkova
    • 1
    • 2
    • 4
  • S. V. Razin
    • 1
    • 2
    • 3
  • Y. S. Vassetzky
    • 2
    • 3
    • 4
  1. 1.Institute of Gene BiologyRussian Academy of SciencesMoscowRussia
  2. 2.LIA1066 “Laboratoire franco-russe de recherche en oncologie”VillejuifFrance
  3. 3.Biological FacultyMoscow State UniversityMoscowRussia
  4. 4.CNRS UMR8126, Universite Paris Sud 11, Institut de Cancerologie Gustave RoussyVillejuifFrance

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