Molecular Biology

, Volume 52, Issue 2, pp 151–164 | Cite as

Epigenetic Mechanisms of Blood-Pressure Regulation

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Abstract

The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

Keywords

blood pressure hypertension epigenetic mechanisms 

Abbreviations

BP

blood pressure

EH

essential hypertension

HD

hypertensive disease

SNP

single nucleotide polymorphism

RAAS

renin-angiotensin-aldosterone system

SAM

S-adenosylmethionine

SAH

S-adenosylhomocysteine

5mCyt

5-methylcytosine

5hmCyt

5-hydroxymethyl cytosine

PNMT

phenylethanolamine-N-methyltransferase

ENaC

epithelial sodium channel

ACE

angiotensin-converting enzyme

11β-HSD2

11-β-hydroxysteroid dehydrogenase type 2

CYP11B1

11–β-hydroxylase

CYP11B2

aldosterone synthase

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  1. 1.Institute of Cytology and GeneticsSiberian Branch of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia

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