Molecular Biology

, Volume 48, Issue 4, pp 468–484 | Cite as

Ribosome: Lessons of a molecular factory construction

  • O. V. Sergeeva
  • P. V. Sergiev
  • A. A. Bogdanov
  • O. A. Dontsova


The ribosome is a macromolecular complex responsible for protein biosynthesis. Two subunits of the bacterial ribosome contain three RNA molecules of more than 4000 nt in total and more than 50 proteins. Ribosome assembly is an intricate multistep process, which is vital for the cell. The review summarizes the current concepts of the mechanisms sustaining bacterial ribosome assembly in the cell and in vitro model systems. Some details of assembling this machine are still unknown.


Escherichia coli ribosome translation RNA helicase GTPase RNA methyltransferase ribonucleoprotein complex 


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Copyright information

© Pleiades Publishing, Inc. 2014

Authors and Affiliations

  • O. V. Sergeeva
    • 1
    • 3
  • P. V. Sergiev
    • 1
    • 2
  • A. A. Bogdanov
    • 1
    • 2
  • O. A. Dontsova
    • 1
    • 2
  1. 1.Chemistry DepartmentMoscow State UniversityMoscowRussia
  2. 2.Belozersky Institute of Physico-Chemical BiologyMoscow State UniversityMoscowRussia
  3. 3.Skolkovo Institute of Science and TechnologySkolkovo, Moscow RegionRussia

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