Molecular Biology

, Volume 47, Issue 3, pp 321–342

Regulated expression systems for gene therapy

Reviews

DOI: 10.1134/S0026893313030023

Cite this article as:
Bruter, A.V., Avdeev, A.V. & Belyavsky, A.V. Mol Biol (2013) 47: 321. doi:10.1134/S0026893313030023

Abstract

Gene therapy is a promising and rapidly developing field of modern medicine and is expected to improve or even cure the diseases that are incurable with classical therapies. The logics of the development of gene therapy in the nearest future will require the systems wherein a regulation is possible for expression of therapeutic genes. The review considers the currently available regulated gene therapeutic systems, which can be divided into two main classes. One includes the systems wherein external inducers are used to trigger therapeutic gene expression. Systems of the other class are autoregulated and function without an external inducer. The most important first-class expression systems are based on the regulation by tetracycline, rapamycin derivative-induced dimerization, steroid hormones, regulatory RNAs, and physical factors. The most important systems of the second class are regulated by oxygen or glucose levels.

Keywords

gene therapy gene expression regulated systems tetracycline-dependent systems dimerization inducers rapamycin-dependent systems nuclear hormones hypoxia-inducible systems glucose-regulated systems 

Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • A. V. Bruter
    • 1
  • A. V. Avdeev
    • 1
  • A. V. Belyavsky
    • 1
  1. 1.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

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