Molecular Biology

, Volume 43, Issue 6, pp 897–916 | Cite as

Effector proteins of chlamydiae

  • A. S. Karyagina
  • A. V. Alexeevsky
  • S. A. Spirin
  • N. A. Zigangirova
  • A. L. Gintsburg
Reviews

Abstract

This review summarizes the recently published data on the molecular mechanisms of Chlamydiae-host cell interaction, first of all, on chlamydial effector proteins. Such proteins, along with type III transport system proteins, which transfer many effector proteins into the host cytoplasm, are attractive targets for drug therapy of chlamydial infections. The majority of the data concerns two species, Chlamydia trachomatis and Chlamydophila pneumoniae. The C. trachomatis protein TARP, which is presynthesized in elementary bodies, plays an essential role in the initial stages of infection. The pathogen proteins that are involved in the next stage, which is the intracellular inclusion traffic to the centrosome, are C. trachomatis CT229 and C. pneumoniae Cpn0585, which interact with cell Rab GTPases. In C. trachomatis, IncA plays a key role in the fusion of chlamydial inclusions, CT847 modulates the life cycle of the host cell, and LDA3 is essential for the acquisition of nutrients. The protease CPAF and the inclusion membrane proteins IncG and CADD are involved in suppressing apoptosis of infected cells. The proteases CPAF and CT441 and the deubiquitinating protein ChlaDub1 help the pathogen to evade the immune response.

Key words

chlamydial effector proteins inclusion membrane proteins type III transport system Chlamydia trachomatis Chlamydia pneumoniae 

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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • A. S. Karyagina
    • 1
    • 2
  • A. V. Alexeevsky
    • 3
    • 4
  • S. A. Spirin
    • 3
    • 4
  • N. A. Zigangirova
    • 1
  • A. L. Gintsburg
    • 1
  1. 1.Gamaleya Institute of Epidemiology and MicrobiologyRussian Academy of Medical SciencesMoscowRussia
  2. 2.All-Russia Institute of Agricultural BiotechnologyRussian Academy of Agricultural SciencesMoscowRussia
  3. 3.Belozersky Institute of Physico-Chemical BiologyMoscow State UniversityMoscowRussia
  4. 4.Institute of System StudiesRussian Academy of SciencesMoscowRussia

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