Molecular Biology

, Volume 42, Issue 1, pp 9–19 | Cite as

Circulating DNA in the blood and its application in medical diagnosis

  • S. N. TamkovichEmail author
  • V. V. Vlassov
  • P. P. Laktionov


Circulating nucleic acids were discovered more than 30 years ago, but did not attract much attention until the past decade. This review summarizes the data on the sources of extracellular DNA circulating in the blood, features of its circulation, and pathways of its removal. The possibility of using circulating DNA in medical diagnosis is discussed.

Key words

circulating DNA apoptosis necrosis active secretion nucleases early noninvasive diagnosis of cancer 


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Copyright information

© Pleiades Publishing, Ltd. 2008

Authors and Affiliations

  • S. N. Tamkovich
    • 1
    • 2
    Email author
  • V. V. Vlassov
    • 1
  • P. P. Laktionov
    • 1
  1. 1.Institute of Chemical Biology and Fundamental Medicine, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia

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