Reconstruction of ancestral regulatory signals along a transcription factor tree
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A model and an algorithm were developed to reconstruct the ancestral regulatory signals, first and foremost, for DNA-protein interactions, at inner nodes of a transcription factor phylogenetic tree on the basis of the modern signal distribution. The algorithm simultaneously infers the evolutionary scenario as a set of tree edges along which the signal diverged to the greatest extent. The model and algorithm were tested with simulation data and biological findings on the NrdR, MntR, and LacI signals.
Key wordsevolutionary scenario regulatory signal frequency matrix evolution along a tree transcription factor tree
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