, Volume 87, Issue 6, pp 745–756 | Cite as

Histidine Acid Phytases of Microbial Origin

  • N. P. BalabanEmail author
  • A. D. Suleimanova
  • E. V. Shakirov
  • M. R. Sharipova


This review is focused on analysis of the biological diversity of phytase-producing microorganisms capable of degrading phytate to inorganic phosphate. General approaches to microbial phytase classification are discussed, with a particular emphasis on histidine acid phytases (HAPs), which catalyze specific cleaving of myo-inositol hexakisphosphate. The effect of glycosylation and various effectors on enzyme thermostability and activity of phytases are described. The data on the biosynthesis of histidine acid phytases, their substrate specificity, and on the mechanism of myo-inositol hexakisphosphate hydrolysis are considered. A conclusion is made concerning the biotechnological potential of this group of microbial enzymes.


histidine acid phytases microorganisms myo-inositol hexakisphosphate biochemical properties substrate specificity phytate hydrolysis 



The work was supported by the State Competitiveness Enhancement Program of the Kazan (Volga region) Federal University among the leading world scientific education centers and by the grant of the Russian Science Foundation no. 16-16-04062.


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© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • N. P. Balaban
    • 1
    Email author
  • A. D. Suleimanova
    • 1
  • E. V. Shakirov
    • 1
    • 2
  • M. R. Sharipova
    • 1
  1. 1.Kazan (Volga region) Federal UniversityKazan, 420021 Russia
  2. 2.The University of Texas at AustinTexasUnited States

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