Chemo-bio catalyzed synthesis of R-1-phenylethyl acetate over bimetallic PdZn catalysts, lipase, and Ru/Al2O3. Part II
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One-pot synthesis of R-1-phenyethylacetate at 70°C was investigated using three different catalysts simultaneously, namely a bimetallic PdZn/Al2O3 as a hydrogenation catalyst, an immobilized lipase as an acylation catalyst and Ru/Al2O3 as a racemization catalyst. The most active bimetallic catalyst was PdZn/Al2O3 calcined at 300°C and reduced at 400°C, whereas the most selective although less active catalyst was the one being calcined and reduced at 500°C. The highest selectivity to R-1-phenylethyl acetate over this catalyst was 32 at 48% conversion. Ru/Al2O3 was confirmed to have a positive effect on the formation of the desired product, although it was not very active in the racemization during one-pot synthesis.
KeywordsLipase Acetophenone Ethylbenzene Immobilize Lipase Acyl Donor
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