Journal of Evolutionary Biochemistry and Physiology

, Volume 54, Issue 5, pp 374–382 | Cite as

Comparative Characterization of Rat Strains (Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT, SHR, BD-IX) by Their Behavior, Hormonal Level and Antioxidant Status

  • E. A. RybnikovaEmail author
  • O. V. Vetrovoi
  • M. Yu. Zenko
Comparative and Ontogenic Physiology


The rat strains Wistar, Wistar–Kyoto, Sprague Dawley, Long Evans, LT (low CNS excitability threshold), SHR, BD-IX (“Biocollection of the Pavlov Institute of Physiology”) were comparatively screened for the indicators of hormonal and antioxidant status as well as behavior. In male rats, the following characteristics were evaluated: behavioral (locomotor activity, anxiety level, depressive-like behavior in the Prosolt forced swim test), hormonal (corticosterone, dehydroepiandrosterone–DHEA, thyroid-stimulating hormone–TSH, thyroxine and testosterone levels) and blood antioxidative activity. Considering our data on physiological phenotyping the above rat strains, physiological maps were created for each strain and a specific descriptive biocollection format was elaborated to represent relevant information as a publicly available online resource ( which can be helpful in choosing an experimental object and instrumental in analyzing data obtained on certain rat strains.

Key words

bioresource collection laboratory rat strains behavioral phenotype anxiety level corticosteroid hormones thyroid hormones blood antioxidant activity 


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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • E. A. Rybnikova
    • 1
    Email author
  • O. V. Vetrovoi
    • 1
  • M. Yu. Zenko
    • 1
  1. 1.Pavlov Institute of PhysiologyRussian Academy of SciencesSt. PetersburgRussia

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