Effect of Early Sucrose Diet on Ethanol Preference and Behavior in Male and Female Wistar Rats
The effect of adolescent sucrose diet on ethanol preference was studied in female and male Wistar rats. Our data show less pronounced ethanol preference in females. In males, pubertal exposure to sucrose was crucial for further ethanol preference, suggesting that cross-sensitization is more inherent to males than females, for whom the increased anxiety factor proved to be more significant. Finally, it was shown that in rats of both sexes habitual alcohol intake determins ethanol preference in the two-bottle test. Overall, our study demonstrates sex differences in ethanol preference as well as its anxiolytic properties.
Key wordsethanol anxiety sex differences rats two-bottle test open field
Unable to display preview. Download preview PDF.
- 1.Shaidukova, L.K., Gendernaya narkologiya (Gender Narcology), Kazan, 2007.Google Scholar
- 3.Schukit, M.A., Drug and Alcohol Abuse. A Clinical Guide to Diagnosis and Treatment, 5th Ed., New York, 2000.Google Scholar
- 9.Dorofeikova, M.V., Filatova, E.V., Orlov, A.A., and Egorov, A.Yu., Early sucrose diet increases ethanol preference in rats, Dokl. Akad. Nauk, 2017, vol. 475, no. 3, pp. 1–3.Google Scholar
- 11.Zakharova, E., Starosciak, A., Wade, D., and Izenwasser, S., Sex differences in the effects of social and physical environment on novelty-induced exploratory behavior and cocaine-stimulated locomotor activity in adolescent rats, Behav. Brain Res., 2012, vol. 230, no. 1, pp. 92–99.CrossRefPubMedPubMedCentralGoogle Scholar
- 14.Fernández, M.S., Fabio, M.C., Miranda-Morales, R.S., Virgolini, M.B., De Giovanni, L.N., Hansen, C., Wille-Bille, A., Nizhnikov, M.E., Spear, L.P., and Pautassi, R.M., Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stressinduced anxiety response, Alcohol, 2016, vol. 51, pp. 89–100.CrossRefPubMedPubMedCentralGoogle Scholar
- 16.Sakharkar, A.J., Tang, L., Zhang, H., Chen, Y., Grayson, D.R., and Pandey, S.C., Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats, Int. J. Neuropsychopharmacol., 2014, vol. 17, no. 12, pp. 2057–2067.CrossRefPubMedPubMedCentralGoogle Scholar
- 22.Vivian, J.A., Green, H.L., Young, J.E., Majerksy, L.S., Thomas, B.W., Shively, C.A., et al., Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis): long-term characterization of sex and individual differences, Alcoholism Clin. Exper. Res., 2001, vol. 25, pp. 1087–1097.CrossRefGoogle Scholar
- 25.Marco, E.M., Ballesta, J.A., Irala, C., Hernández, M.D., Serrano, M.E., Mela, V., López-Gallardo, M., and Viveros, M.P., Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences, Pharmacol. Biochem. Behav., 2017, vol. 152, pp. 68–80. doi: 10.1016/j.pbb.2016.11.005CrossRefPubMedGoogle Scholar