Relict forms of copper-binding centers in human blood coagulation factor VIII

  • K. A. Moshkov
  • V. G. Maslov
  • V. E. Stefanov
Short Communications


Amino Acid Residue Evolutionary Biochemistry Blue Copper Coagulation Factor VIII Human Factor VIII 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Orlova, N.A., Kovnir, S.V., Vorobiev, I.I., Gabibov, A.G., and Vorobiev, A.I., Blood clotting factor VIII: from evolution to therapy, Acta Naturae, 2013, vol. 5, no. 2(17), pp. 19–39.PubMedCentralPubMedGoogle Scholar
  2. 2.
    Shen, B.W., Spiegel, P.C., Chang, C.-H., Huh, J.-W., Lee, J.-S., Kim, J., Kim, Y.-H., and Stoddard, B.L., The tertiary structure and domain organization of coagulation factor VIII, Blood, 2008, vol. 111, no. 3, pp. 1240–1247.CrossRefPubMedCentralPubMedGoogle Scholar
  3. 3.
    Ngo, J.C.K., Huang, M., Roth, D.A., Furie, B.C., and Furie, B., Crystal structure of human factor VIII: implications for formation of the factor IXafactor VIIIa complex, Structure, 2008, vol. 16, no. 4, pp. 597–606.CrossRefPubMedGoogle Scholar
  4. 4.
    Pemberton, S., Lindley, P., Zaitsev, V., Card, G., Tuddenham, E.G.D., and Kemball-Cook, G.A., molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin, Blood, 1997, vol. 89, no. 7, pp. 2413–2421.PubMedGoogle Scholar
  5. 5.
    Zaitseva, I., Zaitsev, V., Card, G., Moshkov, K., Bax, B., Ralph, A., and Lindley, P., X-ray structure of human ceruloplasmin at 3.1 Å: nature of the copper centres, J. Biol. Inorg. Chem., 1996, vol. 1, pp. 15–23.CrossRefGoogle Scholar
  6. 6.
    Moshkov, K.A., Zaitsev, V.N., Grishina, T.V., and Stefanov, V.E., Multinuclear blue copperproteins: the evolutionary design, J. Evol. Biochem. Physiol., 2014, vol. 50, No. 3, pp. 189–205.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  • K. A. Moshkov
    • 1
  • V. G. Maslov
    • 2
    • 3
  • V. E. Stefanov
    • 1
  1. 1.St. Petersburg State UniversitySt. PetersburgRussia
  2. 2.St. Petersburg National Research University of Information Technologies, Mechanics and OpticsSt. PetersburgRussia
  3. 3.St. Petersburg State Polytechnic UniversitySt. PetersburgRussia

Personalised recommendations