Blood supply as a factor regulating pacemaker activity of the rat uterine horn

  • K. V. KazaryanEmail author
  • N. G. Hunanyan
  • N. N. Melkonyan
Comparative and Ontogenic Physiology


The effect of ischemia of the uterine artery supplying blood to the main rhythmogenic ovarian zone of the uterine horn in non-pregnant rats was investigated. Parameters of pacemaker activity of the given locus and all the subsequent pacemaker areas up to the cervix were studied under the influence of ischemia. The greatest changes of the amplitude, frequency and burst duration time of spike activities were recorded in the ovarian end of horn. The uterine corpus and cervical end of horn were less affected by ischemia. However, amplitude of the slow-wave oscillations increased by more than one and a half in these conditions. Data obtained allow us to state about presence of certain connection between the ovarian end of horn and uterine cervix. Morphological studies revealed strong vascularization of the upper part of uterine horn.

Key words

uterus uterine horn ovarian part cervical part uterine cervix spike activity slow-wave activity 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Garfield, R.E. and Maner, W.L., Physiology and Electrical Activity of Uterine Contractions, Semin. Cell Dev. Biol., 2007, vol. 18, no. 3, pp. 289–295.PubMedCrossRefGoogle Scholar
  2. 2.
    Mancinelli, R., Guariglia, L., Racanicchi, C., Bertuzzi, A., Salinari, S., and Vitelli, R., In vitro Motility of Non-Pregnant Rat Uterine Horns, Quar. J. Exp. Physiol., 1988, vol. 73, pp. 459–469.Google Scholar
  3. 3.
    Kazaryan, K.V., Hunanyan, N.G., and Akopyan, R.R., The Characters of Electrophysiological Properties in Various Parts of Uterus and Bordering Area of Rat Uterine Tube, Ross. Fiziol. Zhurn. im. I.M. Sechenova, 2010, vol. 96, no. 10, pp. 981–987.Google Scholar
  4. 4.
    Maul, H., Maner, W.L., Saade, G.R., and Garfield, R.E,. The Physiology of Uterine Contractions, Clin. Perinatol., 2003, vol. 30, pp. 665–676.PubMedCrossRefGoogle Scholar
  5. 5.
    Bortoff, A., Myogenic Control of Intestinal Motility, Physiol. Rev., 1976, vol. 56, no. 2, pp. 418–435.PubMedGoogle Scholar
  6. 6.
    Hamilton, W.F., Circulation, vol. 2 (Handbook of Physiology Series, Section 2), 1963, American Physiol. Soc., Bethseda.Google Scholar
  7. 7.
    Wray, S., Duggins, K., Iles, R., Nyman, L., and Osman, V., The Effect of Metabolic Inhibition and Intracellular pH on Rat Uterine Force Production, Exp. Physiol., 1992, vol. 77, pp. 307–319.PubMedGoogle Scholar
  8. 8.
    Even, M.D., Laughlin, M.H., Krause, G.F., and van Saal, F.S., Differences in Blood Flow to Uterine Segments and Placentae in Relation to Sex, Intrauterine Location and Side in Pregnant Rats, J. Reprod. Fertil., 1994, vol. 102, pp. 245–252.PubMedCrossRefGoogle Scholar
  9. 9.
    Harrison, N., Larcombe-McDouall, J.B., Earley, L., and Wray, S., An in vivo Study of the Effects of Ischaemia on Uterine Contraction, Intracellular pH and Metabolites in the Rat, J. Physiol., 1994, vol. 476, pp. 349–354.PubMedGoogle Scholar
  10. 10.
    Larcombe-McDouall, J.B., Harrison, N., and Wray, S., The in vivo Relationship between Blood Flow, Contractions, pH and Metabolites in the Rat Uterus, Pflugers Arch-Eur. J. Physiol., 1998, vol. 435, pp. 810–817.CrossRefGoogle Scholar
  11. 11.
    Mc Laren, A. and Michie, D., Control of Prenatal Growth in Mammals, Nature, 1960, vol. 187, pp. 363–365.CrossRefGoogle Scholar
  12. 12.
    von Saal, F. and Dhar, M., Blood Flow in Uterine Loop Artery and Loop Vein Is Bidirectional in the Mouse: Implications for Transport of Steroids between Fetuses, Physiol. Behav., 1992, vol. 52, pp. 163–171.CrossRefGoogle Scholar
  13. 13.
    Crane, L.H. and Martin, L., Pacemaker Activity in the Myometrium of the Oestrous Rat: in vivo Studies using Video-Laparoscopy, Reprod. Fertil. Dev., 1991, vol. 3, pp. 519–527.PubMedCrossRefGoogle Scholar
  14. 14.
    Chilingaryan, A.M., The New Calcium-Adenosine Triphosphate Method for the Detection of Interorgan Microcirculator Way, Dokl. Akad. Nauk Armenii, 1986, vol. 82, no. 1, pp. 66–71.Google Scholar
  15. 15.
    Garfield, R.E., Bytautiene, E., Vedernikov, Y.P., Marshall, J.S., and Romero, R., Modulation of Rat Uterine Contractility by Mast Cells and Their Mediators, Am. J. Obstet. Gynecol., 2000, vol. 183, no. 1, pp.118–125.PubMedGoogle Scholar
  16. 16.
    Houdeau, E., Rossano, B., and Prud’homme, M.J., Regional and Muscle Layer Variations in Cholinergic Nerve Control of the Rat Myometrium during the Oestrous Cycle, Auton. Neurosci., 2003, vol. 104, no. 1, pp. 1–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Cavaco-Goncalves, S., Marques, C.C., Horta, A.E., and Fiqueroa, J.P., Increased Cervical Electrical Activity during Oestrus in Progestagen Treated Ewes: Possible Role in Sperm Transport, Anim. Reprod. Sci., 2006, vol. 93, pp. 360–365.PubMedCrossRefGoogle Scholar
  18. 18.
    Buhimschi, C.S., Saade, G.R., Buhimschi, I.A., Gokdeniz, R., Boyle, M.B., and Garfield, R.E., Effect of Stimulatory and Inhibitory Drugs on Uterine Electrical Activity Measured Noninvasively from the Abdominal Surface of Pregnant Rats, Amer. J. Obstet. Gynecol., 2000, vol. 183, pp. 68–75.Google Scholar
  19. 19.
    Hertelendy, F. and Zakar, T., Prostaglandins and the Myometrium and Cervix, Prostaglandins Leukot. Essent. Fatty Acids, 2004, vol. 70, no. 2, pp. 207–222.PubMedCrossRefGoogle Scholar
  20. 20.
    Pajntar, M., Verdenik, I., Pusenjak, S., Rudel, D., and Leskosek, B., Activity of Smooth Muscles in Human Cervix and Uterus, Eur. J. Obstet. Gynecol. Reprod. Biol., 1998, vol. 79, no. 2, pp. 199–204.PubMedCrossRefGoogle Scholar
  21. 21.
    Paintar, M., Leskosek, B., Rudel, D., and Verdenik, I., Contribution of Cervical Smooth Muscle Activity to the Duration of Latent and Active Phases of Labour, Br. J. Obstet. Gynecol., 2001, vol. 108, no. 5, pp. 533–538.CrossRefGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2013

Authors and Affiliations

  • K. V. Kazaryan
    • 1
    Email author
  • N. G. Hunanyan
    • 1
  • N. N. Melkonyan
    • 1
  1. 1.Orbeli Institute of PhysiologyNational Academy of SciencesYerevanRepublic of Armenia

Personalised recommendations