“Zonal model” of description of homeostasis

  • V. A. Kotolupov
  • V. F. Levchenko
Problem Papers

DOI: 10.1134/S0022093009020133

Cite this article as:
Kotolupov, V.A. & Levchenko, V.F. J Evol Biochem Phys (2009) 45: 301. doi:10.1134/S0022093009020133


In this work, peculiarities of functioning of living organisms, which are connected with function of maintenance of homeostasis, are discussed. Many authors wrote about homeostasis, but, as a rule, from positions of some particular disciplines, which prevented from combining the already known facts and concepts in frame of the total approach explaining physiological processes occurring in the organism as the integral system. Specifically, the insufficient attention was paid, in our opinion, to homeorhesis and analysis of such aspect of maintenance of homeostasis as use by the organism of multifunctional possibilities of organs and other structural-functional components. In this work, an attempt has been made at filling this gap: a new, “zonal” model of description of homeostasis is proposed, the already known regularities of functioning of living systems are considered, and their list is supplemented. In our opinion, this can promote solution of general problems of physiology and medicine and allows better understanding of organization of processes in living organisms. Besides, in terms of our approach, it is easier to explain some physiological changes occurring in the process of evolution.

Key words

homeostasis homeorhesis adaptation homeostatic zone 

Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • V. A. Kotolupov
    • 1
  • V. F. Levchenko
    • 2
  1. 1.Center of Systemic MedicineVipavaSlovenia
  2. 2.Sechenov Institute of Evolutionary Physiology and BiochemistryRussian Academy of SciencesSt. PetersburgRussia

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