Dynamics of organ blood flow in rats in postnatal ontogenesis

  • B. M. Belichenko
  • T. A. Grigorieva
  • U. V. Shyyrapai
  • R. I. Aizman
  • K. A. Shoshenko
Comparative and Ontogenic Physiology


In the 4-, 13-, 30-, and 65–90-day old anestetized Wistar rats (8–15 rats in each group) the voluminous blood flow rate was measured in liver, kidney, small intestine wall, and in the predominantly white gracilis muscle of femur. A LAKK-01 laser-Doppler flowmeter and its cutaneous (for kidney) and needle (for other organs) probes were used; they provided estimation of blood flow to the tissue depth of about 1 mm. It has been found that the blood flow rates (per organ mass unit) fall in liver, intestine, and even more in muscle, whereas increase in kidney, particularly for the first month of life. Calculations show that in adult rats as compared with the 4-day old pups (with their mass exceeding 22 times) the blood flow to muscle, liver, intestine, and kidney should rise (with taking into account the increase of mass of the organs) 14, 17, 18, and 43 times, respectively.

Key words

specific blood flow rate minute blood volume intestine muscle liver kidney ontogenesis rat 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Frolkis, V.V., Cardiovascular System and Age, Vozrastnaya fiziologiya (Age Physiology), Leningrad, 1975, pp. 109–156.Google Scholar
  2. 2.
    Gotschall, R.W., Breay-Pileher, J.C., and Boeleskevy, B.D., Cardiac Output in Adult and Neonatal Rats Utilizing Impedance Cardiography, Am. J. Physiol., 1987, vol. 253, pp. HI298–HI304.Google Scholar
  3. 3.
    Nigmatulina, R.R., Sitdikov, F.G., and Abzalov, R.A., Cardiac Output in Rat Pup Ontogenesis, Fiziol. Zh. SSSR im. I.M. Sechenova, 1988, vol.74, pp. 965–977.Google Scholar
  4. 4.
    Nigmatulina, R.R., Khurgamshin, I.G., and Nasirova, A.G., Effect of Desympathization on the Heart Pump Function at Rat Postnatal Ontogenesis, Ross. Fiziol Zh. im. I.M. Sechenova, 2002, vol. 88, pp. 1567–1577.Google Scholar
  5. 5.
    Belichenko, V.M., Grigorieva, T.A., and Shoshenko, C.A., Muscle Blood Flow Rate in Rats in Ontogenesis, Measured with the Needle Probe of a “LAKK-01” Laser-Doppler Flowmeter, Ross. Fiziol. Zh. im. I.M. Sechenova, 2007, vol. 93, pp. 655–660.PubMedGoogle Scholar
  6. 6.
    Shyyrapai, U.V., Belichenko, V.M., Shoshenko, C.A., and Aizman, R.I., Glomerular Apparatus and Blood Flow in Rat Kidney in Postnatal Ontogenesis, Ross. Fiziol. Zh. im. I.M. Sechenova, 2008, vol. 94, pp. 456–464.PubMedGoogle Scholar
  7. 7.
    Grigorieva, T.A., Belichenko, V.M., Aizman, R.I., and Shoshenko, C.A., Using Intravascular Autoradiography for an Estimation of Proliferative Activity of Rat Mesenteric Microvessel Endothelial Cells during the First Month of Postnatal Development, J. Vasc. Res., 2007, vol. 44, pp. 403–409.PubMedCrossRefGoogle Scholar
  8. 8.
    Laughlin, M.Y. and Armstrong, R.B., Rat Muscle Blood Flows as a Function of Time during Prolonged Slow Treadmill Exercise, Am. J. Physiol. 1983, vol. 244, pp. H814–H824.PubMedGoogle Scholar
  9. 9.
    Kozlova, V.I., Mach, E.S., and Sidorov, V.V., Instruktsiya po primeneniyu lasernogo analizatora kapillyarnogo krovotoka LAKK-01 (Insrtuction of Use of the LAKK-01 Laser Analyzer of Capillary Blood Flow), Moscow, 2002.Google Scholar
  10. 10.
    Ishise, S., Pegram, B.L., Yamamoto, J., Kitamura, Y., and Fronlich, E.D., Reference Sample Microsphere Method; Cardiac Output and Blood Flows in Conscious Rat, Am. J. Physiol., 1980, vol. 239, pp. H443–H449.PubMedGoogle Scholar
  11. 11.
    Turganbaeva, A.S., Baranov, V.I., and Shoshenko, K.A., Regional Distribution of the Blood Flow in Conscious Rats at Elevated External Temperature, Fiziol. Zh. SSSR im. I.M. Sechenova, 1996, vol. 82, no. 8–9, pp. 59–65.Google Scholar
  12. 12.
    Delp, V.D., Evans, M.V., and Duan, Ch., Effects of Aging on Cardiac Output, Regional Blood Flow and Body Composition in Fischer-344 Rats, J. Appl. Physiol., 1998, vol. 85, no. 5, pp. 1813–1822.PubMedGoogle Scholar
  13. 13.
    Shoshenko, K.A., Organ Blood Flow under Conditions of the Motor Rest in Rodents with Different Body Masses, Zh. Evol. Biokhim. Fiziol., 2004, vol. 40, pp. 254–260.PubMedGoogle Scholar
  14. 14.
    Shoshenko, K.A., Krovenosnyie kapillyary (Blood Capillaries), Novosibirsk, 1975.Google Scholar
  15. 15.
    Karpitzkii, V.V., Slovenov, S.V., and Rerich, R.A., Determination of Cardiac Output in Small Laboratory Animals by the Method of Tetrapolar Rheography, Patol. Fiziol. Eksp. Terap., 1986, no. 1, pp. 74–77.Google Scholar
  16. 16.
    Kuznetzov, S.V., Goncharov, N.V., and Glashkina, L.M., Change of Parameters of Functioning of the Cardiovascular and Respiratory Systems in Rats of Different Age under Action of Small Doses of the Cholinesterase Inhibitor Phosphacol, Zh. Evol. Biokhim. Fiziol., 2005, vol. 41, pp. 260–267.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  • B. M. Belichenko
    • 1
  • T. A. Grigorieva
    • 2
  • U. V. Shyyrapai
    • 2
  • R. I. Aizman
    • 1
  • K. A. Shoshenko
    • 1
  1. 1.Research Institute of PhysiologySiberian Branch of the Russian Academy of Medical SciencesNovosibirskRussia
  2. 2.Novosibirsk State Pedagogic UniversityNovosibirskRussia

Personalised recommendations