JETP Letters

, Volume 101, Issue 11, pp 772–775 | Cite as

Excitation wave propagation in a patterned multidomain cardiac tissue

  • N. N. Kudryashova
  • A. S. Teplenin
  • Y. V. Orlova
  • K. I. AgladzeEmail author


Electrospun fibrous mats are widely used in the contemporary cardiac tissue engineering as the substrates for growing cardiac cells. The substrate with chaotically oriented nanofibers leads to the growth of cardiac tissue with randomly oriented, but internally morphologically anisotropic clusters or domains. The domain structure affects the stability of the excitation propagation and we studied the stability of the propagating excitation waves versus the average size of the domains and the externally applied excitation rate. In an experimental model based on neonatal rat cardiac tissue monolayers, as well as in the computer simulations, we have found that an increase in domain sizes leads to the decrease in the critical stimulation frequencies, thus evidencing that larger domains are having a higher arrhythmogenic effect.


JETP Letter Domain Size Cardiac Tissue Excitation Wave Anisotropy Ratio 
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Copyright information

© Pleiades Publishing, Inc. 2015

Authors and Affiliations

  • N. N. Kudryashova
    • 1
  • A. S. Teplenin
    • 1
  • Y. V. Orlova
    • 2
  • K. I. Agladze
    • 1
    Email author
  1. 1.Laboratory of Biophysics of Excitable SystemsMoscow Institute of Physics and Technology (State University)Dolgoprudnyi, Moscow regionRussia
  2. 2.iCeMS Research BuildingYoshida HonmachiKyotoJapan

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