Doklady Chemistry

, Volume 483, Issue 1, pp 266–267 | Cite as

Synthesis of Deuterated or Tritiated Glycine and Its Methyl Ester

  • V. P. ShevchenkoEmail author
  • L. A. Andreeva
  • I. Yu. Nagaev
  • N. F. Myasoedov


Heating glycine (Gly) and methyl glycinate (GlyOCH3) supported on 5% Pd/C or 5% Pt/C in a deuterium or tritium gas atmosphere gave the isotope-labeled products. The experiments were carried out at 180°C for 10 min. The deuterium atom inclusion under these conditions averaged up to 1.8 atoms per molecule for Gly and up to 1.0 atom per molecule for GlyOCH3. The reaction with tritium gas gave labeled products with a specific radioactivity of 27–31 Ci/mmol for Gly and 18 Ci/mmol for GlyOCH3.



This work was partially supported by the Russian Science Foundation (project no. 16–14–00077) and Programs of the Presidium of the RAS “Fundamental Research for the Development of Biomedical Technologies” and “Molecular and Cell Biology and Post-Genomic Technologies.”


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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • V. P. Shevchenko
    • 1
    Email author
  • L. A. Andreeva
    • 1
  • I. Yu. Nagaev
    • 1
  • N. F. Myasoedov
    • 1
  1. 1.Institute of Molecular Genetics, Russian Academy of SciencesMoscowRussia

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