Preparation of Succinyl-Chitin Nanoparticles for Biomedical Applications
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The N-acylation of partially deacetylated chitin nanofibers with succinic anhydride gave N-succinyl-chitin. The introduction of succinyl groups into chitin nanofibers followed by sonication of the aqueous dispersion of N-succinyl-chitin gives rise to a stable aqueous dispersion (with particle hydrodynamic radius of 350 nm and ζ-potential of –22 mV). The particle morphology simultaneously changes from rod-like with (100–500) × (6–15) nm size to spherical with 160–400 nm size, whereas the chitin crystal structure barely changes.
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- 15.Kiroshka, V.V., Petrova, V.A., Chernyakov, D.D., Bozhkova, Y.O., Kiroshka, K.V., Baklagina, Y.G., Romanov, D.P., Kremnev, R.V., and Skorik, Y.A., J. Mater. Sci.: Mater. Med., 2017, vol. 28, no. 1, p. 21.Google Scholar