Doklady Chemistry

, Volume 480, Issue 2, pp 114–116 | Cite as

Preparation of Succinyl-Chitin Nanoparticles for Biomedical Applications

  • V. A. Petrova
  • M. M. Galagudza
  • Y. A. SkorikEmail author


The N-acylation of partially deacetylated chitin nanofibers with succinic anhydride gave N-succinyl-chitin. The introduction of succinyl groups into chitin nanofibers followed by sonication of the aqueous dispersion of N-succinyl-chitin gives rise to a stable aqueous dispersion (with particle hydrodynamic radius of 350 nm and ζ-potential of –22 mV). The particle morphology simultaneously changes from rod-like with (100–500) × (6–15) nm size to spherical with 160–400 nm size, whereas the chitin crystal structure barely changes.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kritchenkov, A.S., Andranovits, S., and Skorik, Y.A., Russ. Chem. Rev., 2017, vol. 86, no. 3, pp. 231–239.CrossRefGoogle Scholar
  2. 2.
    Berezin, A.S., Lomkova, E.A., and Skorik, Y.A., Russ. Chem. Bull., 2012, vol. 61, no. 4, pp. 781–795.CrossRefGoogle Scholar
  3. 3.
    Kumar, M.N.V.R., Muzzarelli, R.A.A., Muzzarelli, C., Sashiwa, H., and Domb, A.J., Chem. Rev., 2004, vol. 104, no. 12, pp. 6017–6084.CrossRefPubMedGoogle Scholar
  4. 4.
    Dash, B.C., Rethore, G., Monaghan, M., Fitzgerald, K., Gallagher, W., and Pandit, A., Biomaterials, 2010, vol. 31, no. 32, pp. 8188–8197.CrossRefPubMedGoogle Scholar
  5. 5.
    Minami, S., Suzuki, H., Okamoto, Y., Fujinaga, T., and Shigemasa, Y., Carbohydr. Polym., 1998, vol. 36, no. 2–3, pp. 151–155.CrossRefGoogle Scholar
  6. 6.
    Kato, Y., Onishi, H., and Machida, Y., Biomaterials, 2000, vol. 21, no. 15, pp. 1579–85.CrossRefPubMedGoogle Scholar
  7. 7.
    Panevin, A.A., Golyshev, A.A., Skorik, Y.A., Zhuravskii, S.G., and Sonin, D.L., Pharm. Chem. J., 2017, vol. 50, no. 11, pp. 711–714.CrossRefGoogle Scholar
  8. 8.
    Skorik, Y.A., Kritchenkov, A.S., Moskalenko, Y.E., Golyshev, A.A., Raik, S.V., Whaley, A.K., Vasina, L.V., and Sonin, D.L., Carbohydr. Polym., 2017, vol. 166, pp. 166–172.CrossRefPubMedGoogle Scholar
  9. 9.
    Skorik, Y.A., Golyshev, A.A., Kritchenkov, A.S., Gasilova, E.R., Poshina, D.N., Sivaram, A.J., and Jayakumar, R., Carbohydr. Polym., 2017, vol. 162, pp. 49–55.CrossRefPubMedGoogle Scholar
  10. 10.
    Ifuku, S., Iwasaki, M., Morimoto, M., and Saimoto, H., Carbohydr. Polym., 2012, vol. 90, no. 1, pp. 623–627.CrossRefPubMedGoogle Scholar
  11. 11.
    Golyshev, A.A., Moskalenko, Y.E., and Skorik, Y.A., Russ. Chem. Bull., 2015, vol. 64, no. 5, pp. 1168–1171.CrossRefGoogle Scholar
  12. 12.
    Hirano, S. and Moriyasu, T., Carbohydr. Polym., 2004, vol. 55, no. 3, pp. 245–248.CrossRefGoogle Scholar
  13. 13.
    Kiroshka, V.V., Yurchuk, T.A., Repin, N.V., Petrova, V.A., Gofman, I.V., Skorik, Y.A., Kiroshka, E.V., and Bondarenko, T.P., Bull. Exp. Biol. Med., 2014, vol. 158, no. 1, pp. 153–158.CrossRefPubMedGoogle Scholar
  14. 14.
    Lu, P. and Hsieh, Y.-L., Carbohydr. Polym., 2010, vol. 82, no. 2, pp. 329–336.CrossRefGoogle Scholar
  15. 15.
    Kiroshka, V.V., Petrova, V.A., Chernyakov, D.D., Bozhkova, Y.O., Kiroshka, K.V., Baklagina, Y.G., Romanov, D.P., Kremnev, R.V., and Skorik, Y.A., J. Mater. Sci.: Mater. Med., 2017, vol. 28, no. 1, p. 21.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • V. A. Petrova
    • 1
  • M. M. Galagudza
    • 2
  • Y. A. Skorik
    • 1
    • 2
    Email author
  1. 1.Institute of Macromolecular CompoundsRussian Academy of SciencesSt. PetersburgRussia
  2. 2.Almazov National Medical Research CentreMinistry of Health of the Russian FederationSt. PetersburgRussia

Personalised recommendations