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Doklady Chemistry

, Volume 480, Issue 2, pp 114–116 | Cite as

Preparation of Succinyl-Chitin Nanoparticles for Biomedical Applications

  • V. A. Petrova
  • M. M. Galagudza
  • Y. A. SkorikEmail author
Chemistry

Abstract

The N-acylation of partially deacetylated chitin nanofibers with succinic anhydride gave N-succinyl-chitin. The introduction of succinyl groups into chitin nanofibers followed by sonication of the aqueous dispersion of N-succinyl-chitin gives rise to a stable aqueous dispersion (with particle hydrodynamic radius of 350 nm and ζ-potential of –22 mV). The particle morphology simultaneously changes from rod-like with (100–500) × (6–15) nm size to spherical with 160–400 nm size, whereas the chitin crystal structure barely changes.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • V. A. Petrova
    • 1
  • M. M. Galagudza
    • 2
  • Y. A. Skorik
    • 1
    • 2
    Email author
  1. 1.Institute of Macromolecular CompoundsRussian Academy of SciencesSt. PetersburgRussia
  2. 2.Almazov National Medical Research CentreMinistry of Health of the Russian FederationSt. PetersburgRussia

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