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Biophysics

, Volume 64, Issue 1, pp 57–61 | Cite as

The Role of Erythrocyte Receptors in Regulation of the Conformation and Distribution of Hemoglobin

  • G. V. MaksimovEmail author
  • O. V. Slatinskaya
  • E. S. Tkhor
  • N. A. Anisimov
  • S. N. Mamaeva
  • V. V. Shutova
CELL BIOPHYSICS
  • 16 Downloads

Abstract—Using Raman spectroscopy, atomic force microscopy, and laser interferometry we found that variations in insulin-like growth factor (IGF-1) and purinergic compounds such as ATP in the blood influence the hemoglobin distribution and hematoporhyrin conformation in hemoglobin in erythrocytes. Our results suggest that receptor activation promotes changes in conformation of cytoskeletal protein molecules and hemoglobin.

Keywords: erythrocyte IGF-1 ATP hemoglobin hematoporphyrin cytoplasm 

Notes

COMPLIANCE WITH ETHICAL STANDARDS

Conflict of interests. The authors declare that they have no conflict of interest.

Statement of compliance with standards of research involving humans as subjects. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants involved in the study.

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Copyright information

© Pleiades Publishing, Inc. 2019

Authors and Affiliations

  • G. V. Maksimov
    • 1
    Email author
  • O. V. Slatinskaya
    • 1
  • E. S. Tkhor
    • 1
  • N. A. Anisimov
    • 2
  • S. N. Mamaeva
    • 3
  • V. V. Shutova
    • 4
  1. 1.Moscow State UniversityMoscowRussia
  2. 2.National Scientific Center Institute of Biomedical ProblemsMoscowRussia
  3. 3.Ammosov Northeastern Federal UniversityYakutskRussia
  4. 4.Ogarev National Research Mordovia State UniversitySaranskRussia

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