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Ultrasonic Monitoring of Blood Coagulation and Fibrinolysis under Intensive Blood Flow

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Abstract

An acoustic study of the processes of coagulation and fibrinolysis in intense blood flows under the influence of several drugs was carried out. The processes of blood coagulation and fibrinolysis have been observed in vitro in real time using optical and acoustical tools. When fibrin microclots formed in the flow, an automatic injector provided an input of a fibrinolytic drug. The experiments have shown that the method allows the monitoring of fibrinolysis in blood plasma as well as in whole blood and could be applied for the effective control of the injection of fibrinolytics. Acoustic registration was shown to be sufficient to estimate the efficiency of the fibrinolysis. The developed software-hardware complex allows one to test fibrinolytic drugs and could be used to develop protocols for their administration. The prospects for creating new classes of portable devices for hemostasis correction have been opened up.

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ACKNOWLEDGMENTS

This work was supported by the Russian Foundation for Basic Research, projects no. 14-04-01193 and 16-34-01180.

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Authors and Affiliations

  1. National Research Center for Hematology, Moscow, , 125167 , Russia

    D. A. Ivlev & S. G. Uzlova

  2. Moscow Institute of Physics and Technology, 141700, Dolgoprudny, Moscow, Russia

    Sh. N. Shirinli & K. G. Guria

Authors
  1. D. A. Ivlev
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  2. Sh. N. Shirinli
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  3. S. G. Uzlova
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  4. K. G. Guria
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Corresponding author

Correspondence to D. A. Ivlev.

Additional information

Translated by I. Shipounova

1Abbreviations: AM, amplitude module; FEI, fibrinolysis efficiency index.

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Ivlev, D.A., Shirinli, S.N., Uzlova, S.G. et al. Ultrasonic Monitoring of Blood Coagulation and Fibrinolysis under Intensive Blood Flow. BIOPHYSICS 63, 637–643 (2018). https://doi.org/10.1134/S0006350918040085

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  • DOI: https://doi.org/10.1134/S0006350918040085

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