Hypofractionated irradiation of the solid form of Ehrlich ascites carcinoma in mice by a thin scanning proton beam
- 13 Downloads
The dynamics of the growth of Ehrlich ascites carcinoma in mice of the SHK line exposed to hypofractionated high-dose irradiation by a thin scanning proton beam has been analyzed for different irradiation volumes and different time intervals (from 4 to 24 hours) between two 30-Gy fractions. Irradiation of the gross tumor volume and the planned target volume was performed within the Bragg peak; the energy of protons at the outlet of the accelerator ranged from 85 to 100 MeV. Hypofractionated irradiation of the gross tumor volume of Ehrlich ascites carcinoma resulted in a more pronounced antitumor effect than the irradiation of the planned target volume. The effect did not depend on the interval between the irradiation episodes.
Keywordshypofractionation scanning pencil beam proton therapy Ehrlich ascites carcinoma mice
gross tumor volume
planned target volume
Unable to display preview. Download preview PDF.
- 1.I. A. Gulidov, Radiats. Onkol. Yadern. Med. 1 (34), 34 (2013).Google Scholar
- 2.V. V. Glebovskaya and A. V. Petrovskii, Radiats. Onkol. Yadern. Med. 1 (20), 20 (2014).Google Scholar
- 3.E. V. Khmelevskii, Radiats. Onkol. Yadern. Med. 1 (28), 28 (2013).Google Scholar
- 5.T. Ogata, T. Teshima, K. Kagawa, et al., Cancer Res. 65 (1), 113 (2005).Google Scholar
- 13.G. A. Raskin, R. V. Orlova, A. E. Protasova, et al., Vopr. Onkol. 59 (6), 694 (2013).Google Scholar
- 15.D. C. Weber, C. Ares, F. Albertini, et al., Pediatr. Blood Cancer (2015). http://onlinelibrary.wiley.com/doi/10.1002/pbc.25864/epdf.Google Scholar
- 16.Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes (Official Journal of the European Union, L 276, 2010; Rus-LASA, St. Petersbirg, 2012).Google Scholar
- 17.ICRU Report 62: Prescribing, Recording and Reporting Photon Beam Therapy (International Commission on Radiation Units and Measurements, Bethesda, 1999).Google Scholar
- 20.M. V. Filimonova, S. E. Ul’yanenko, L. I. Shevchenko, et al., Radiats. Biol. Radioekol. 55 (3), 260 (2015).Google Scholar