, Volume 59, Issue 4, pp 646–650 | Cite as

Information theory of ageing: Studying the effect of bone marrow transplantation on the life span of mice

  • A. V. Karnaukhov
  • E. V. Karnaukhova
  • L. A. Sergievich
  • N. A. Karnaukhova
  • E. V. Bogdanenko
  • A. A. Smirnov
  • I. A. Manokhina
  • V. N. Karnaukhov
Complex Systems Biophysics


In this paper the method of life span extension of multicellular organisms (human) using reservation of stem cells followed by autotransplantation has been proposed. As the efficiency of this method results from the information theory of ageing, it is important to verify it experimentally testing the basic concepts of the theory. Taking it into consideration, the experiment on bone marrow transplantation to old mice from young closely related donors of the inbred line was carried out. It has been shown that transplanted animals exhibited a survival advantage, a mean life span increased by 34% as compared to the control. This result not only demonstrates the efficiency of the proposed method for life span extension of multicellular organisms, but also confirms the basis of the information theory of ageing.


bone marrow transplantation ageing germ line information theory of ageing life span GFP+ mice crossing-over recombination of genes surviving 


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Copyright information

© Pleiades Publishing, Inc. 2014

Authors and Affiliations

  • A. V. Karnaukhov
    • 1
  • E. V. Karnaukhova
    • 1
  • L. A. Sergievich
    • 1
  • N. A. Karnaukhova
    • 1
  • E. V. Bogdanenko
    • 2
  • A. A. Smirnov
    • 3
  • I. A. Manokhina
    • 1
  • V. N. Karnaukhov
    • 1
  1. 1.Institute of Cell BiophysicsRussian Academy of SciencesPushchino, Moscow RegionRussia
  2. 2.Institute of General Pathology and Pathophysiology Russian Academy of Medical SciencesMoscowRussia
  3. 3.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesPushchino, Moscow RegionRussia

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