Analysis of protein-on-DNA binding profiles determined with ChIP-seq reveals possible interaction of specific transcription factors with RNA polymerase II during transcription elongation
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It is considered that almost all transcription factors stay on promoter while RNA polymerase II “clears” the promoter and “proceeds” to elongation transcribing mRNA. However, analysis of some specific transcription factors and RNA polymerase II binding profiles on DNA, detected with ChIP-seq method, revealed possibility of interaction between transcription factors and RNA polymerase II in the process of transcription elongation.
Keywordstranscription initiation transcription elongation RNA polymerases transcription regulators
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