, Volume 57, Issue 2, pp 140–143 | Cite as

Analysis of protein-on-DNA binding profiles determined with ChIP-seq reveals possible interaction of specific transcription factors with RNA polymerase II during transcription elongation

  • A. A. Belostotsky
Molecular Biophysics


It is considered that almost all transcription factors stay on promoter while RNA polymerase II “clears” the promoter and “proceeds” to elongation transcribing mRNA. However, analysis of some specific transcription factors and RNA polymerase II binding profiles on DNA, detected with ChIP-seq method, revealed possibility of interaction between transcription factors and RNA polymerase II in the process of transcription elongation.


transcription initiation transcription elongation RNA polymerases transcription regulators 


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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • A. A. Belostotsky
    • 1
  1. 1.Institute for Genetics and Selection of Industrial MicroorganismsMoscowRussia

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