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Biophysics

, Volume 54, Issue 1, pp 47–50 | Cite as

Nonlinear effects of lidocaine on polymorphism of ventricular arrhythmias

  • A. V. Moskalenko
Complex Systems Biophysics

Abstract

For the first time experimental evidence for the nonlinear dependence of the antiarrhythmic effect of the Na-channel blocker on its concentration was obtained. The experiments were carried out with the use of a preparation of the mammalian heart wall. As a blocker, lidocaine was used. It was found that conventional “antiarrhythmic” concentrations of lidocaine made ventricular tachycardias indeed more monomorphic, but at lower concentrations lidocaine unexpectedly increased the probability for the ventricular tachycardias to appear more polymorphic. The biophysical reason of this phenomenon is discussed.

Key words

ventricular tachycardia normalized-value analysis of electrocardiographic variability antiarrhythmics sodium channel blockers 

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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  1. 1.Institute of Theoretical and Experimental BiophysicsRussian Academy of SciencesPushchino, Moscow RegionRussia

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