Nonlinear effects of lidocaine on polymorphism of ventricular arrhythmias
For the first time experimental evidence for the nonlinear dependence of the antiarrhythmic effect of the Na-channel blocker on its concentration was obtained. The experiments were carried out with the use of a preparation of the mammalian heart wall. As a blocker, lidocaine was used. It was found that conventional “antiarrhythmic” concentrations of lidocaine made ventricular tachycardias indeed more monomorphic, but at lower concentrations lidocaine unexpectedly increased the probability for the ventricular tachycardias to appear more polymorphic. The biophysical reason of this phenomenon is discussed.
Key wordsventricular tachycardia normalized-value analysis of electrocardiographic variability antiarrhythmics sodium channel blockers
Unable to display preview. Download preview PDF.
- 1.A. B. Medvinskii and N. I. Kukushkin, Vestn. Aritmol. No. 35, 49 (2004).Google Scholar
- 2.Cardiac Arrhythmias: Their Mechanisms, Diagnosis, and Management, 2nd Edition, Ed. by W. J. Mandel (Lippincott, Pa, 1987).Google Scholar
- 3.V. L. Doshchitsin, Ros. Kardiol. Zh. No. 1, 46 (1999).Google Scholar
- 6.A. V. Moskalenko, N. I. Kukushkin, C. F. Starmer, et al., Biophysics 46, 313 (2001).Google Scholar
- 7.A. V. Moskalenko and El’kin, Chaos Solitons Fractals No. 1, 66 (2008).Google Scholar
- 8.N. I. Kukushkin, V. Yu. Sidorov, K. N. Gorbacheva, and A. V. Savin, Vestn. Aritmol. No. 37, 47 (2004).Google Scholar
- 9.N. I. Kukushkin, V. Yu. Sidorov, A. B. Medvinskii, et al., Biophysics 43, 995 (1998).Google Scholar
- 10.D. Yu. Sarancha, A. B. Medvinsky, N. I. Kukushkin, et al., Biophysics 42, 491 (1997).Google Scholar
- 11.A. V. Moskalenko, A. B. Medvinsky, I. A. Tikhonova, et al., Automated Researcher Workplace Exemplified with a Multielectrode Myocardial Mapping Setup (Progress-Traditsiya, Moscow, 2000), pp. 131–134 [in Russian].Google Scholar