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Biochemistry (Moscow)

, Volume 83, Supplement 1, pp S176–S189 | Cite as

Interactions between the Translation Machinery and Microtubules

  • E. M. ChudinovaEmail author
  • E. S. Nadezhdina
Review

Abstract

Microtubules are components of eukaryotic cytoskeleton that are involved in the transport of various components from the nucleus to the cell periphery and back. They also act as a platform for assembly of complex molecular ensembles. Ribonucleoprotein (RNP) complexes, such as ribosomes and mRNPs, are transported over significant distances (e.g. to neuronal processes) along microtubules. The association of RNPs with microtubules and their transport along these structures are essential for compartmentalization of protein biosynthesis in cells. Microtubules greatly facilitate assembly of stress RNP granules formed by accumulation of translation machinery components during cell stress response. Microtubules are necessary for the cytoplasm-to-nucleus transport of proteins, including ribosomal proteins. At the same time, ribosomal proteins and RNA-binding proteins can influence cell mobility and cytoplasm organization by regulating microtubule dynamics. The molecular mechanisms underlying the association between the translation machinery components and microtubules have not been studied systematically; the results of such studies are mostly fragmentary. In this review, we attempt to fill this gap by summarizing and discussing the data on protein and RNA components of the translation machinery that directly interact with microtubules or microtubule motor proteins.

Keywords

ribosome polysome mRNP mRNA kinesin dynein stress granule 

Abbreviations

APC

adenomatous polyposis coli

eEF

eukaryotic translation elongation factor

Egl

Egalitarian

eIF

eukaryotic translation initiation factor

Hu antigen

antigen in human paraneoplastic neurological syndromes

JAKMIP1

Janus kinase and microtubule-interacting protein 1

KIF

kinesin family member

MAP1B LC1

microtubule-associated protein 1B light chain 1

mRNP

messenger ribonucleoprotein

PABP

poly(A)-binding protein

RpL

large subunit ribosomal protein

RpS

small subunit ribosomal protein

UTR

mRNA untranslated region

YB1

Y box-binding protein 1

ZBP1

zipcode-binding protein 1

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Institute of Protein ResearchRussian Academy of SciencesPushchinoRussia
  2. 2.Peoples’ Friendship University of RussiaMoscowRussia
  3. 3.Lomonosov Moscow State UniversityMoscowRussia

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