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Biochemistry (Moscow)

, Volume 83, Supplement 1, pp S56–S61 | Cite as

Archaeal Flagella as Biotemplates for Nanomaterials with New Properties

  • S. N. Beznosov
  • M. G. Pyatibratov
  • O. V. FedorovEmail author
Review

Abstract

At the end of 1980s, regions of the polypeptide chain of bacterial flagella subunits (flagellins) responsible for different properties of these protein polymers were identified by structural studies. It was found that the N-and C-terminal regions are responsible for the polymerization properties of subunits, and the central region is responsible for antigenic properties of the flagellum. Soon after that, it was proposed to use variability of the central flagellin domain for directed modification to impart new properties to the flagellum surface. Such studies of flagella and other polymeric structures of bacterial origin thrived. However bacterial polymers have some shortcomings, mainly their instability to dissociating effects. This shortcoming is absent in archaeal flagella. A limiting factor was the lack of the three-dimensional structure of archaeal flagellins. A method was developed that allowed modifying flagella of the halophilic archaeon Halobacterium salinarum in a peptide that connects positively charged ions. Later, corresponding procedures were used that allowed preparing the anode material for a lithiumion battery whose characteristics 4-5-fold exceeded those of batteries commonly used in industrial production. We describe other advantages of archaeal flagella over bacterial analogs when used in nanotechnology.

Keywords

Archaea flagella archaella protein modification biotemplated nanomaterials 

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • S. N. Beznosov
    • 1
  • M. G. Pyatibratov
    • 1
  • O. V. Fedorov
    • 1
    Email author
  1. 1.Institute of Protein ResearchRussian Academy of SciencesPushchinoRussia

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