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Biochemistry (Moscow)

, Volume 83, Issue 12–13, pp 1448–1458 | Cite as

Alterations in WNT Signaling in Leukemias

  • T. I. Fetisov
  • E. A. Lesovaya
  • M. G. Yakubovskaya
  • K. I. Kirsanov
  • G. A. BelitskyEmail author
Review

Abstract

The WNT/β–catenin signaling pathway plays an important role in the differentiation and proliferation of hematopoietic cells. In recent years, special attention has been paid to the role of impairments in the WNT signaling path–way in pathogenesis of malignant neoplasms of the hematopoietic system. Disorders in the WNT/β–catenin signaling in leukemias identified to date include hypersensitivity to the WNT ligands, epigenetic repression of WNT antagonists, over–expression of WNT ligands, impaired β–catenin degradation in the cytoplasm, and changes in the activity of the TCF/Lef transcription factors. At the molecular level, these impairments involve overexpression of the FZD protein, hypermethylation of the SFRP, DKK, WiF, Sox, and CXXC gene promoters, overexpression of Lef1 and plakoglobin, mutations in GSK3β, and β–catenin phosphorylation by the BCR–ABL kinase. This review is devoted to the systematization of these data.

Keywords

leukemias hemopoiesis WNT signaling pathway WNT ligands β–catenin WNT antagonists transcription factors TCF/Lef 

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Copyright information

© Pleiades Publishing, Inc. 2018

Authors and Affiliations

  • T. I. Fetisov
    • 1
  • E. A. Lesovaya
    • 1
    • 2
  • M. G. Yakubovskaya
    • 1
  • K. I. Kirsanov
    • 1
    • 3
  • G. A. Belitsky
    • 1
    Email author
  1. 1.Blokhin National Medical Research Center of OncologyMoscowRussia
  2. 2.Pavlov Ryazan State Medical UniversityRyazanRussia
  3. 3.Peoples’ Friendship University of RussiaMoscowRussia

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