Biochemistry (Moscow)

, Volume 83, Issue 9, pp 1124–1138 | Cite as

Enhancement of Declarative Memory: From Genetic Regulation to Non-invasive Stimulation

  • D. V. BryzgalovEmail author
  • I. L. Kuznetsova
  • E. I. RogaevEmail author


The problem of memory enhancement is extremely important in intellectual activity areas and therapy of different types of dementia, including Alzheimer’s disease (AD). The attempts to solve this problem have come from different research fields. In the first part of our review, we describe the results of targeting certain genes involved in memory-associated molecular pathways. The second part of the review is focused on the deep stimulation of brain structures that can slow down memory loss in AD. The third part describes the results of the use of non-invasive brain stimulation techniques for memory modulation, consolidation, and retrieval in healthy people and animal models. Integration of data from different research fields is essential for the development of efficient strategies for memory enhancement.


memory Alzheimer’s disease brain stimulation hippocampus CREB pathway 



α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid


brain-derived neurotrophic factor


CCAAT enhancer-binding protein


cAMP response element-binding protein


deep brain stimulation


dorsolateral prefrontal cortex


designer receptor exclusively activated by designer drugs


(functional) magnetic resonance imaging


insulin-like growth factor

IIS pathway

insulin/IGF-I-like signaling pathway




protein kinase Mζ


transcranial alternating current stimulation


transcranial direct current stimulation


transcranial magnetic stimulation


tetracycline responsive element


tropomyosin-related kinase B


tetracycline transactivator




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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Memory, Oscillations, Brain States (MOBS) Team, Brain Plasticity UnitCNRS UMR 8249, ESPCI ParisParisFrance
  2. 2.Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia
  3. 3.Department of PsychiatryUniversity of Massachusetts Medical SchoolWorcesterUSA
  4. 4.Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia
  5. 5.Faculty of Bioengineering and BioinformaticsLomonosov Moscow State UniversityMoscowRussia

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