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Biochemistry (Moscow)

, Volume 83, Issue 9, pp 1068–1074 | Cite as

Dynamic Microtubules in Alzheimer’s Disease: Association with Dendritic Spine Pathology

  • E. I. Pchitskaya
  • V. A. Zhemkov
  • I. B. BezprozvannyEmail author
Mini-Review

Abstract

Alzheimer’s disease (AD) is the most common incurable neurodegenerative disorder that affects the processes of memory formation and storage. The loss of dendritic spines and alteration in their morphology in AD correlate with the extent of patient’s cognitive decline. Tubulin had been believed to be restricted to dendritic shafts, until recent studies demonstrated that dynamically growing tubulin microtubules enter dendritic spines and promote their maturation. Abnormalities of tubulin cytoskeleton may contribute to the process of dendritic spine shape alteration and their subsequent loss in AD. In this review, association between tubulin cytoskeleton dynamics and dendritic spine morphology is discussed in the context of dendritic spine alterations in AD. Potential implications of these findings for the development of AD therapy are proposed.

Keywords

Alzheimer’s disease dendritic spines tubulin microtubule dynamics EB3 

Abbreviations

AD

Alzheimer’s disease

APP

amyloid-precursor protein

EB3

end-binding protein 3

MT

microtubule

PS1 (2)

Presenilin 1(2)

+TIPs

microtubule plus-end-tracking proteins

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • E. I. Pchitskaya
    • 1
  • V. A. Zhemkov
    • 1
  • I. B. Bezprozvanny
    • 1
    • 2
    Email author
  1. 1.Laboratory of Molecular Neurodegeneration, Department of Medical PhysicsPeter the Great St. Petersburg Polytechnic UniversitySt. PetersburgRussia
  2. 2.Department of PhysiologyUT Southwestern Medical Center at DallasDallasUSA

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