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Biochemistry (Moscow)

, Volume 83, Issue 9, pp 1057–1067 | Cite as

Anti-amyloid Therapy of Alzheimer’s Disease: Current State and Prospects

  • S. A. Kozin
  • E. P. Barykin
  • V. A. MitkevichEmail author
  • A. A. Makarov
Review

Abstract

Drug development for the treatment of Alzheimer’s disease (AD) has been for a long time focused on agents that were expected to support endogenous β-amyloid (Aβ) in a monomeric state and destroy soluble Aβ oligomers and insoluble Aβ aggregates. However, this strategy has failed over the last 20 years and was eventually abandoned. In this review, we propose a new approach to the anti-amyloid AD therapy based on the latest achievements in understanding molecular causes of cerebral amyloidosis in AD animal models.

Keywords

Alzheimer’s disease amyloid-β isoaspartate zinc protein-protein complexes cerebral β-amyloidosis 

Abbreviations

AD

Alzheimer’s disease

DMAs

disease-modifying agents

β-amyloid

isoAβ

β-amyloid with isomerized Asp7 residue

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • S. A. Kozin
    • 1
  • E. P. Barykin
    • 1
  • V. A. Mitkevich
    • 1
    Email author
  • A. A. Makarov
    • 1
  1. 1.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

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