Biochemistry (Moscow)

, Volume 83, Issue 9, pp 1007–1008 | Cite as

Different Pathways to Neurodegeneration

  • E. I. RogaevEmail author


The current issue is dedicated to the studies of neurodegenerative diseases and memory. Molecular mechanisms and mutant genes have already been revealed for many neurodegenerative diseases. However, in many cases the cause of selective death of neurons in different brain regions remains unclear. Genetic predisposition and aging are well established risk factors in many neurodegenerative diseases. A large body of evidence has been obtained that shows an important role of immune factors in the modulation of neurodegenerative processes. The progress in the treatment of neurodegenerative diseases requires new cell models for identification of non-canonical pharmacological targets and development of approaches for memory regulation. Gene therapy technologies based on genome editing and RNA interference methods are among promising approaches for repairing primary molecular defects underlying neurodegenerative pathologies.


neurodegeneration mutant genes aging memory Alzheimer’s disease 


  1. 1.
    Sherwood, C. C., Stimpson, C. D., Raghanti, M. A., Wildman, D. E., Uddin, M., Grossman, L. I., Goodman, M., Redmond, J. C., Bonar, C. J., Erwin, J. M., and Hof, P. R. (2006) Evolution of increased glia-neuron ratios in the human frontal cortex, Proc. Natl. Acad. Sci. USA, 103, 13606–13611.CrossRefPubMedGoogle Scholar
  2. 2.
    Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., Duncan, L., Escott-Price, V., Falcone, G. J., Gormley, P., Malik, R., Patsopoulos, N. A., Ripke, S., Wei, Z., Yu, D., Lee, P. H., Turley, P., et al. (2018) Analysis of shared heritability in common disorders of the brain, Science, 360, eaap8757.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  1. 1.Department of PsychiatryUniversity of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Vavilov Institute of General GeneticsRussian Academy of SciencesMoscowRussia
  3. 3.Center of Genetics and Genetic TechnologiesLomonosov Moscow State UniversityMoscowRussia

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