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Biochemistry (Moscow)

, Volume 83, Issue 5, pp 507–526 | Cite as

Blood-Derived RNA- and microRNA-Hydrolyzing IgG Antibodies in Schizophrenia Patients

  • E. A. Ermakov
  • S. A. Ivanova
  • V. N. Buneva
  • G. A. NevinskyEmail author
Article

Abstract

Abzymes with various catalytic activities are the earliest statistically significant markers of existing and developing autoimmune diseases (AIDs). Currently, schizophrenia (SCZD) is not considered to be a typical AID. It was demonstrated recently that antibodies from SCZD patients efficiently hydrolyze DNA and myelin basic protein. Here, we showed for the first time that autoantibodies from 35 SCZD patients efficiently hydrolyze RNA (cCMP > poly(C) > poly(A) > yeast RNA) and analyzed site-specific hydrolysis of microRNAs involved in the regulation of several genes in SCZD (miR-137, miR-9-5p, miR-219-2-3p, and miR-219a-5p). All four microRNAs were cleaved by IgG preparations (n = 21) from SCZD patients in a site-specific manner. The RNase activity of the abzymes correlated with SCZD clinical parameters. The data obtained showed that SCZD patients might display signs of typical autoimmune processes associated with impaired functioning of microRNAs resulting from their hydrolysis by the abzymes.

Keywords

abzymes schizophrenia patients polyribonucleotide miRNA hydrolysis 

Abbreviations

AID

autoimmune disease

CC

correlation coefficient

MBP

myelin basic protein

MS

multiple sclerosis

SLE

systemic lupus erythematosus

SCZD

schizophrenia

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • E. A. Ermakov
    • 1
    • 2
  • S. A. Ivanova
    • 3
  • V. N. Buneva
    • 1
    • 2
  • G. A. Nevinsky
    • 1
    • 2
    Email author
  1. 1.Institute of Chemical Biology and Fundamental MedicineSiberian Branch of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia
  3. 3.Mental Health Research Institute, Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia

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