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Biochemistry (Moscow)

, Volume 83, Issue 2, pp 87–97 | Cite as

Activation of Yeast Mitochondrial Translation: Who Is in Charge?

  • K. S. Derbikova
  • S. A. Levitsky
  • I. V. Chicherin
  • E. N. Vinogradova
  • P. A. KamenskiEmail author
Review

Abstract

Mitochondrial genome has undergone significant reduction in a course of evolution; however, it still contains a set of protein-encoding genes and requires translational machinery for their expression. Mitochondrial translation is of the prokaryotic type with several remarkable differences. This review is dedicated to one of the most puzzling features of mitochondrial protein synthesis, namely, the system of translational activators, i.e., proteins that specifically regulate translation of individual mitochondrial mRNAs and couple protein biosynthesis with the assembly of mitochondrial respiratory chain complexes. The review does not claim to be a comprehensive analysis of all published data; it is rather focused on the idea of the “core component” of the translational activator system.

Keywords

mitochondria ribosomes translation mRNA translational activators complex assembly 

Abbreviation

cryo-EM

cryo-electron microscopy

PPR

pentatricopeptide repeat

UTR

untranslated region

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • K. S. Derbikova
    • 1
  • S. A. Levitsky
    • 1
  • I. V. Chicherin
    • 1
  • E. N. Vinogradova
    • 1
  • P. A. Kamenski
    • 1
    • 2
    Email author
  1. 1.Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Institute of Living SystemsImmanuel Kant Baltic Federal UniversityKaliningradRussia

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