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Biochemistry (Moscow)

, Volume 83, Issue 1, pp 1–12 | Cite as

Recombinant monoclonal antibodies for rabies post-exposure prophylaxis

  • E. N. IlinaEmail author
  • M. V. Larina
  • T. K. Aliev
  • D. A. Dolgikh
  • M. P. Kirpichnikov
Review
  • 166 Downloads

Abstract

Rabies virus is a prototypical neurotropic virus that causes one of the most dangerous zoonotic diseases in humans. Humanized or fully human monoclonal antibodies (mAb) that neutralize rabies virus would be the basis for powerful post-exposure prophylaxis of rabies in humans, having several significant benefits in comparison with human or equine rabies polyclonal immunoglobulins. The most advanced antibodies should broadly neutralize natural rabies virus isolates, bind with conserved antigenic determinants of the rabies virus glycoprotein, and show high neutralizing potency in assays in vivo. The antibodies should recognize nonoverlapping epitopes if they are used in combination. This review focuses on basic requirements for anti-rabies therapeutic antibodies. The urgency in the search for novel rabies post-exposure prophylaxis and methods of development of anti-rabies human mAb cocktail are discussed. The rabies virus structure and pathways of its penetration into the nervous system are also briefly described.

Keywords

human monoclonal antibodies rabies virus glycoprotein G antigenic site post-exposure prophylaxis rabies immunoglobulin 

Abbreviations

AS

antigenic site

CHO

Chinese hamster ovary tumor cells

ERIG

equine rabies immunoglobulin

(H)RIG

(human) rabies immunoglobulin

IFN

interferon

mAb

mono-clonal antibodies

nACR

nicotine acetylcholine receptor (n-cholinoreceptor)

NBs

Negri bodies

NCAM

neuronal cell adhesion molecule

NGFR or p75NTR

nerve growth factor (p75 neutrophin receptor)

PEP

post-exposure prophylaxis

RABV

rabies virus

RIG

rabies immunoglobulin

STAT

transcription factor

TLRs

toll-like receptors.

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Copyright information

© Pleiades Publishing, Ltd. 2018

Authors and Affiliations

  • E. N. Ilina
    • 1
    Email author
  • M. V. Larina
    • 2
  • T. K. Aliev
    • 3
  • D. A. Dolgikh
    • 1
    • 2
  • M. P. Kirpichnikov
    • 1
    • 2
  1. 1.Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Shemyakin−Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia
  3. 3.Faculty of ChemistryLomonosov Moscow State UniversityMoscowRussia

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