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Biochemistry (Moscow)

, Volume 82, Issue 11, pp 1380–1390 | Cite as

Role of microRNA in development of instability of atherosclerotic plaques

  • I. A. Koroleva
  • M. S. NazarenkoEmail author
  • A. N. Kucher
Review

Abstract

MicroRNAs are small noncoding single-stranded RNAs that regulate gene expression. Today, we see an increasing number of studies highlighting the important role of microRNAs in the development and progression of cardiovascular diseases caused by atherosclerotic lesions of arteries. We review the available scientific data on association of the expression of these biomolecules with instability of atherosclerotic plaques in animal models and humans. We made special emphasis on miR-21, -100, -127, -133, -143/145, -221/222, and -494 because they were analyzed in more than one study. We discuss the possibility of microRNAs using in the diagnosis and therapy of atherosclerosis and its complications.

Keywords

atherosclerosis instability of human atherosclerotic plaques microRNA 

Abbreviations

ECs

endothelial cells

UTR

untranslated region

VSMCs

vascular smooth muscle cells

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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  • I. A. Koroleva
    • 1
  • M. S. Nazarenko
    • 1
    • 2
    • 3
    Email author
  • A. N. Kucher
    • 1
  1. 1.Research Institute of Medical Genetics, Tomsk National Research Medical CenterRussian Academy of SciencesTomskRussia
  2. 2.Research Institute for Complex Issues of Cardiovascular DiseasesSiberian Branch of the Russian Academy of SciencesKemerovoRussia
  3. 3.Siberian State Medical UniversityTomskRussia

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