Biochemistry (Moscow)

, Volume 82, Issue 8, pp 887–893 | Cite as

PDX1: A unique pancreatic master regulator constantly changes its functions during embryonic development and progression of pancreatic cancer

  • T. V. VinogradovaEmail author
  • E. D. Sverdlov


Multifunctional activity of the PDX1 gene product is reviewed. The PDX1 protein is unique in that being expressed exclusively in the pancreas it exhibits various functional activities in this organ both during embryonic development and during induction and progression of pancreatic cancer. Hence, PDX1 belongs to the family of master regulators with multiple and often antagonistic functions.


dedifferentiation transdifferentiation transcription factors suppressor acinar cell duct cell 



epithelial–mesenchymal transition


pancreatic ductal adenocarcinoma


pancreatic and duodenal homeobox 1


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Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.Shemyakin−Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesMoscowRussia

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