Biochemistry (Moscow)

, Volume 82, Issue 1, pp 86–87 | Cite as

Response to comments by V. N. Manskikh: “Do external or internal factors lead to tumor development? It is still unknown”

  • A. V. LichtensteinEmail author


The opinion is presented according to which the “bad luck” hypothesis (Tomasetti, C., and Vogelstein, B. (2015) Science, 347, 78–81), which has recently received experimental confirmation, has the right to exist, and its criticisms are largely unfounded.


cancer “bad luck” hypothesis carcinogenesis mutagenesis external and internal factors cancer prevention 


  1. 1.
    Manskikh, V. N. (2017) Do external or internal factors lead to tumor development? It is still unknown, Biochemistry (Moscow), 82, 81–85.CrossRefGoogle Scholar
  2. 2.
    Berton, O., Hahn, C. G., and Thase, M. E. (2012) Are we getting closer to valid translational models for major depression? Science, 338, 75–79.Google Scholar
  3. 3.
    Wyss-Coray, T., Masliah, E., Mallory, M., McConlogue, L., Johnson-Wood, K., Lin, C., and Mucke, L. (1997) Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer’s disease, Nature, 389, 603–606.CrossRefPubMedGoogle Scholar
  4. 4.
    Jurgelski, W., Hudson, P. M., Falk, H. L., and Kotin, P. (1976) Embryonal neoplasms in the opossum: a new model for solid tumors of infancy and childhood, Science, 193, 328–332.CrossRefPubMedGoogle Scholar
  5. 5.
    Sjoblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D., Leary, R. J., Ptak, J., Silliman, N., Szabo, S., Buckhaults, P., Farrell, C., Meeh, P., Markowitz, S. D., Willis, J., Dawson, D., Willson, J. K. V., Gazdar, A. F., Hartigan, J., Wu, L., Liu, C., Parmigiani, G., Park, B. H., Bachman, K. E., Papadopoulos, N., Vogelstein, B., Kinzler, K. W., and Velculescu, V. E. (2006) The consensus coding sequences of human breast and colorectal cancers, Science, 314, 268–274.CrossRefPubMedGoogle Scholar
  6. 6.
    Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., Hong, S. M., Fu, B., Lin, M. T., Calhoun, E. S., Kamiyama, M., Walter, K., Nikolskaya, T., Nikolsky, Y., Hartigan, J., Smith, D. R., Hidalgo, M., Leach, S. D., Klein, A. P., Jaffee, E. M., Goggins, M., Maitra, A., IacobuzioDonahue, C., Eshleman, J. R., Kern, S. E., Hruban, R. H., Karchin, R., Papadopoulos, N., Parmigiani, G., Vogelstein, B., Velculescu, V. E., and Kinzler, K. W. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses, Science, 321, 1801–1806.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Vogelstein, B., Papadopoulos, N., Velculescu, V. E., Zhou, S., Diaz, L. A., and Kinzler, K. W. (2013) Cancer genome landscapes, Science, 339, 1546–1558.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Tomasetti, C., Marchionni, L., Nowak, M. A., Parmigiani, G., and Vogelstein, B. (2015) Only three driver gene mutations are required for the development of lung and colorectal cancers, Proc. Natl. Acad. Sci. USA, 112, 118–123.CrossRefPubMedGoogle Scholar
  9. 9.
    Hoang, M. L., Kinde, I., Tomasetti, C., McMahon, K. W., Rosenquist, T. A., Grollman, A. P., Kinzler, K. W., Vogelstein, B., and Papadopoulos, N. (2016) Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing, Proc. Natl. Acad. Sci. USA, 113, 9846–9851.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Tomasetti, C., and Vogelstein, B. (2015) Musings on the theory that variation in cancer risk among tissues can be explained by the number of divisions of normal stem cells, arXiv: 1501.05035.Google Scholar
  11. 11.
    Zhu, L., Finkelstein, D., Gao, C., Shi, L., Wang, Y., Lopez-Terrada, D., Wang, K., Utley, S., Pounds, S., Neale, G., Ellison, D., Onar-Thomas, A., and Gilbertson, R. (2016) Multi-organ mapping of cancer risk, Cell, 166, 1132–1146.CrossRefPubMedGoogle Scholar

Copyright information

© Pleiades Publishing, Ltd. 2017

Authors and Affiliations

  1. 1.Institute of CarcinogenesisBlokhin Cancer Research CenterMoscowRussia

Personalised recommendations