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Biochemistry (Moscow)

, Volume 81, Issue 13, pp 1676–1697 | Cite as

Myosin light chain kinase MYLK1: Anatomy, interactions, functions, and regulation

  • A. Y. KhapchaevEmail author
  • V. P. Shirinsky
Review

Abstract

This review discusses and summarizes the results of molecular and cellular investigations of myosin light chain kinase (MLCK, MYLK1), the key regulator of cell motility. The structure and regulation of a complex mylk1 gene and the domain organization of its products is presented. The interactions of the mylk1 gene protein products with other proteins and posttranslational modifications of the mylk1 gene protein products are reviewed, which altogether might determine the role and place of MLCK in physiological and pathological reactions of cells and entire organisms. Translational potential of MLCK as a drug target is evaluated.

Keywords

myosin light chain kinase KRP/telokin mylk1 gene organization and regulation posttranslational modifications protein–protein interactions MLCK-dependent cellular reactions MLCK in pathology 

Abbreviations

CaM

calmodulin

Erk1/2

extracellular regulated kinase-1/2

IFNγ

interferon gamma

IL-1β

interleukin-1beta

KRP

kinase-related protein

MAP-kinase

mitogenactivated protein kinase

MLCK

myosin light chain kinase

MLCP

myosin light chain phosphatase

MYPT1

myosin phosphatase target subunit 1

PKA

cyclic AMP-dependent protein kinase, protein kinase A

PTM

posttranslational modification

RLC

regulatory light chain

ROCK

Rho-associated protein kinase

TNFα

tissue necrosis factor alpha

ZIPK

zip-per-interacting protein kinase

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Russian Cardiology Research and Production CenterMoscowRussia
  2. 2.Lomonosov Moscow State University, Faculty of Fundamental MedicineMoscowRussia

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