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Biochemistry (Moscow)

, Volume 81, Issue 12, pp 1429–1437 | Cite as

Study of age-dependent structural and functional changes of mitochondria in skeletal muscles and heart of naked mole rats (Heterocephalus glaber)

  • S. HoltzeEmail author
  • C. M. Eldarov
  • V. B. Vays
  • I. M. Vangeli
  • M. Yu. VysokikhEmail author
  • L. E. BakeevaEmail author
  • V. P. Skulachev
  • T. B. Hildebrandt
Phenoptosis (Special Issue)

Abstract

Morphometric analysis of mitochondria in skeletal muscles and heart of 6- and 60-month-old naked mole rats (Heterocephalus glaber) revealed a significant age-dependent increase in the total area of mitochondrial cross-sections in studied muscle fibers. For 6- and 60-month-old animals, these values were 4.8 ± 0.4 and 12.7 ± 1.8%, respectively. This effect is mainly based on an increase in the number of mitochondria. In 6-month-old naked mole rats, there were 0.23 ± 0.02 mitochondrial cross-sections per μm2 of muscle fiber, while in 60-month-old animals this value was 0.47 ± 0.03. The average area of a single mitochondrial cross-section also increased with age in skeletal muscles–from 0.21 ± 0.01 to 0.29 ± 0.03 μm2. Thus, naked mole rats show a drastic enlargement of the mitochondrial apparatus in skeletal muscles with age due to an increase in the number of mitochondria and their size. They possess a neotenic type of chondriome accompanied by specific features of mitochondrial functioning in the state of oxidative phosphorylation and a significant decrease in the level of matrix adenine nucleotides.

Key words

naked mole rat morphometry respiration aging ultrastructure mitochondria neoteny 

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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Leibniz Institute for Zoo and Wildlife Research, Department of Reproduction ManagementBerlinGermany
  2. 2.Lomonosov Moscow State University, Belozersky Institute of Physico-Chemical BiologyMoscowRussia

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