Biochemistry (Moscow)

, Volume 81, Issue 11, pp 1274–1283 | Cite as

Myeloid-derived suppressor cells and proinflammatory cytokines as targets for cancer therapy

  • K.-S. N. Atretkhany
  • M. S. DrutskayaEmail author


Myeloid-derived suppressor cells represent a heterogeneous population of immature myeloid cells. Under normal conditions, these cells differentiate into macrophages, dendritic cells, and granulocytes. However, in pathological states such as inflammation, infection, or tumor growth, there is an arrest of their differentiation that results in the accumulation of immature myeloid cells in the organism. In addition, these cells acquire a suppressor phenotype, expressing anti-inflammatory cytokines and reactive oxygen and nitrogen species, and suppress T-cell immune response. Myeloid-derived suppressor cells (MDSC) contribute to cancerogenesis by forming a favorable microenvironment for tumor growth. Proinflammatory cytokines, secreted by tumor cells and the tumor microenvironment, induce angiogenesis and metastasis and promote tumor growth. They also provide signals necessary for survival, accumulation, and function of MDSC. Understanding the mechanisms of myeloid suppressor cell development and the use of proinflammatory cytokine inhibitors may prove beneficial for tumor therapy.


MDSC TNF IL-6 IL-1 tumor microenvironment tumor-associated inflammation 



arginase 1


granulocyte colonystimulating factor


granulocyte-macrophage colony-stimulating factor






inducible NO-synthase


monocyte-macrophage colony-stimulating factor


myeloid-derived suppressor cells


reactive oxygen species


soluble form of TNF


T-cell receptor


transforming growth factor beta


transmembrane TNF


tumor necrosis factor


tumor necrosis factor receptor


regulatory T cells


vascular endothelial growth factor


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Engelhardt Institute of Molecular BiologyMoscowRussia
  2. 2.Biological FacultyLomonosov Moscow State UniversityMoscowRussia

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