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Biochemistry (Moscow)

, Volume 81, Issue 11, pp 1261–1273 | Cite as

Inflammatory immune infiltration in human tumors: Role in pathogenesis and prognostic and diagnostic value

  • A. V. BogolyubovaEmail author
  • P. V. Belousov
Review

Abstract

The cellular microenvironment directly and indirectly influences tumor development and possesses prognostic and in some cases diagnostic value. Over the years, understanding of structural organization of the immune/inflammatory moiety of neoplasms as well as in-depth phenotypic and transcriptomic profiling of its cellular components together provide more and more insights in both basic and translational medical science. In this review, we will discuss the specific roles of various stromal cells and their impact on neoplastic progression as well as address the use of quantitative and phenotypic analysis of immune/inflammatory infiltrate for diagnostics and predicting the clinical course of human malignancies.

Keywords

cellular microenvironment of tumors immune infiltration melanoma breast cancer thyroid cancer colorectal cancer 

Abbreviations

BC

breast cancer

CTL

cytotoxic T lymphocytes

IFN

interferon

IL

interleukin

ILC

innate lymphoid cells

MDSC

myeloid-derived suppressor cells

MSI

microsatellite instability

NCR

natural cytotoxicity receptors

Tregs

regulatory T cells

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© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia
  2. 2.Biological FacultyLomonosov Moscow State UniversityMoscowRussia

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