Biochemistry (Moscow)

, Volume 81, Issue 8, pp 806–818 | Cite as

α-Tocopheryl succinate affects malignant cell viability, proliferation, and differentiation

Review

Abstract

The widespread occurrence of malignant tumors motivates great attention to finding and investigating effective new antitumor preparations. Such preparations include compounds of the vitamin E family. Among them, α-tocopheryl succinate (vitamin E succinate (VES)) has the most pronounced antitumor properties. In this review, various targets and mechanisms of the antitumor effect of vitamin E succinate are characterized. It has been shown that VES has multiple intracellular targets and effects, and as a result VES is able to induce apoptosis in tumor cells, inhibit their proliferation, induce differentiation, prevent metastasizing, and inhibit angiogenesis. However, VES has minimal effects on normal cells and tissues. Due to the variety of targets and selectivity of action, VES is a promising agent against malignant neoplasms. More detailed studies in this area can contribute to development of effective and safe chemotherapeutic preparations.

Keywords

α-tocopheryl succinate apoptosis reactive oxygen species mitochondria tumor cells 

Abbreviations

DAG

diacylglycerol

GPDH

glycerol-3-phosphate dehydrogenase

ROS

reactive oxygen species

SDH

succinate dehydrogenase

SOD

superoxide dismutase

VES

vitamin E succinate

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© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Faculty of BiologyLomonosov Moscow State UniversityMoscowRussia

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