Biochemistry (Moscow)

, Volume 81, Issue 5, pp 445–452 | Cite as

Apoptosis in cryopreserved eukaryotic cells

  • M. A. SavitskayaEmail author
  • G. E. Onishchenko


This review considers apoptosis mechanisms that have been revealed in cryopreserved cells and which can be controlled using different chemical agents, thereby improving the viability of cells after their return to normal conditions. The role of oxidative stress as of the most significant damaging factor is discussed, as well as the reasonability of including antioxidants into cryopreservation/thawing protocols as independent agents or in combination with other compounds.


apoptosis cryopreservation oxidative stress autophagy 



dimethyl sulfoxide


poly(ADP-ribose) polymerase




Rho-associated protein kinase


reactive oxygen species


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© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  1. 1.Lomonosov Moscow State UniversityMoscowRussia

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