Biochemistry (Moscow)

, Volume 81, Issue 4, pp 329–337 | Cite as

Mitochondria as a signaling Hub and target for phenoptosis shutdown

  • P. V. Zolotukhin
  • A. A. Belanova
  • E. V. Prazdnova
  • M. S. Mazanko
  • M. M. Batiushin
  • V. K. Chmyhalo
  • V. A. ChistyakovEmail author


Mitochondria have long been studied as the main energy source and one of the most important generators of reactive oxygen species in the eukaryotic cell. Yet, new data suggest mitochondria serve as a powerful cellular regulator, pathway trigger, and signal hub. Some of these crucial mitochondrial functions appear to be associated with RNP-granules. Deep and versatile involvement of mitochondria in general cellular regulation may be the legacy of parasitic behavior of the ancestors of mitochondria in the host cells. In this regard, we also discuss here the perspectives of using mitochondria-targeted compounds for systemic correction of phenoptotic shifts.


mitochondria regulation systems biology mitochondrial targeting Skulachev ions phenoptosis 


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Copyright information

© Pleiades Publishing, Ltd. 2016

Authors and Affiliations

  • P. V. Zolotukhin
    • 1
  • A. A. Belanova
    • 1
  • E. V. Prazdnova
    • 1
  • M. S. Mazanko
    • 1
  • M. M. Batiushin
    • 1
  • V. K. Chmyhalo
    • 1
  • V. A. Chistyakov
    • 1
    Email author
  1. 1.Southern Federal UniversityAcademy of Biology and BiotechnologyRostov-on-DonRussia

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