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Biochemistry (Moscow)

, Volume 80, Issue 13, pp 1723–1733 | Cite as

Regulation of Zygotic Genome and Cellular Pluripotency

  • D. V. OnichtchoukEmail author
  • A. S. Voronina
Review

Abstract

Events, manifesting transition from maternal to zygotic period of development are studied for more than 100 years, but underlying mechanisms are not yet clear. We provide a brief historical overview of development of concepts and explain the specific terminology used in the field. We further discuss differences and similarities between the zygotic genome activation and in vitro reprogramming process. Finally, we envision the future research directions within the field, where biochemical methods will play increasingly important role.

Key words

zebrafish ZGA MBT pluripotency Oct4 Nanog 

Abbreviations and definitions

ESC

embryonic stem cells

IPSC

induced pluripotent stem cells

maternal transcription

transcription that occurs in the egg and stops in the first meiotic prophase

MBT

midblastula transition (a particular case of MZT, which occurs in several organisms. MBT is a moment of time, when ZGA, degradation of maternal transcripts, desynchronization of cell cycle, and locomotor activity of the cells start. The definition MBT is mostly applied to amphibians, fish, and Drosophila)

MZT

maternal to zygotic transition (several events happening after fertilization until establishment of zygotic control over development including ZGA, degradation of maternal transcripts, desynchronization of cell cycle, and acquisition of cell motility. The term MZT can be applied to all metazoans)

pluripotency

capacity of cells to differentiate along cell lineages contributing to all embryonic but not extraembryonic tissues. Early cells of vertebrate embryos before beginning of gastrulation, ESC, derived from mammals, birds, and fish and IPSC are pluripotent

totipotency

unrestricted capacity of cells to differentiate along cell lineages contributing to all embryonic and extraembryonic tissues. Zygote is totipotent by definition; early mammalian cells are also totipotent

ZGA

zygotic genome activation (start of zygotic transcription, which occurs in species-specific interval after fertilization).

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.Developmental Biology UnitUniversity of FreiburgFreiburgGermany
  2. 2.Research Center of Biotechnology RAS (Bach Institute of Biochemistry)MoscowRussia

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