Advertisement

Biochemistry (Moscow)

, Volume 80, Issue 12, pp 1626–1628 | Cite as

Effect of long-term treatment with antioxidant SkQ1 Added to drinking water on cytochromes P450 level in rat liver

  • K. N. MyasoedovaEmail author
  • D. N. Silachev
Article

Abstract

Mitochondria-targeted cationic antioxidant plastoquinonyl decyltriphenylphosphonium (SkQ1) added to drinking water in therapeutic doses (250 nmol/kg per day) for a long time (up to 24 months) does not induce cytochromes P450 in rat liver.

Keywords

cytochrome P450 SkQ1 mitochondria-targeted antioxidant 

Abbreviations

SkQ1

plastoquinonyl decyltriphenylphosphonium

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Furge, L. L., and Guengerich, F. P. (2006. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: an introduction, Biochem. Mol. Biol. Educ., 34, 66–74.CrossRefPubMedGoogle Scholar
  2. 2.
    Coon, M. J. (2002. Enzyme ingenuity in biological oxidations: a trail leading to cytochrome P450, J. Biol. Chem., 277, 28351–28363.CrossRefPubMedGoogle Scholar
  3. 3.
    Ekroos, M., and Sjogren, T. (2006. Structural basis for ligand promiscuity in cytochrome P450 3A4, Proc. Natl. Acad. Sci. USA, 103, 13682–13687.PubMedCentralCrossRefPubMedGoogle Scholar
  4. 4.
    Guengerich, F. P. (2006. A malleable catalyst dominates the metabolism of drugs, Proc. Natl. Acad. Sci. USA, 103, 13565–13566.PubMedCentralCrossRefPubMedGoogle Scholar
  5. 5.
    Lyakhovich, V. V., and Tsyrlov, I. B. (1981) Induction of the Enzymes of Xenobiotics Metabolism [in Russian], Nauka, Novosibirsk.Google Scholar
  6. 6.
    Myasoedova, K. N. (2008. New findings in studies on cytochrome P450, Biochemistry (Moscow), 73, 965–969.CrossRefGoogle Scholar
  7. 7.
    Antonenko, Y. N., Avetisyan, A. V., Bakeeva, L. E., Chernyak, B. V., Chertkov, V. A., Domnina, L. V., Ivanova, O. Yu., Izyumov, D. S., Khailova, L. S., Klishin, S. S., Korshunova, G. A., Lyamzaev, K. G., Muntyan, M. S., Nepryakhina, O. K., Pashkovskaya, A. A., Pletyushkina, O. Yu., Pustovidko, A. V., Roginsky, V. A., Rokitskaya, T. I., Ruuge, E. K., Saprunova, V. B., Severina, I. I., Simonyan, R. A., Skulachev, I. V., Skulachev, M. V., Sumbatyan, N. V., Sviryaeva, I. V., Tashlitsky, V. N., Vassiliev, J. M., Vysokikh, M. Yu., Yaguzhinsky, L. S., Zamyatnin, A. A., Jr., and Skulachev, V. P. (2008. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. I. Cationic plastoquinone derivatives: synthesis and in vitro studies, Biochemistry (Moscow), 73, 12731287.CrossRefGoogle Scholar
  8. 8.
    Skulachev, V. P., Anisimov, V. N., Antonenko, Y. N., Bakeeva, L. E., Chernyak, B. V., Erichev, V. P., Filenko, O. F., Kalinina, N. I., Kapelko, V. I., Kolosova, N. G., Kopnin, B. P., Korshunova, G. A., Lichinitser, M. R., Obukhova, L. A., Pasyukova, E. G., Pisarenko, O. I., Roginsky, V. A., Ruuge, E. K., Senin, I. I., Severina, I. I., Skulachev, M. V., Spivak, I. M., Tashlitsky, V. N., Tkachuk, V. A., Vyssokikh, M. Y., Yaguzhinsky, L. S., and Zorov, D. B. (2009. An attempt to prevent senescence: a mitochondrial approach, Biochim. Biophys. Acta, 1787, 437–461.CrossRefPubMedGoogle Scholar
  9. 9.
    Severin, F. F., Severina, I. I., Antonenko, Y. N., Rokitskaya, T. I., Cherepanov, D. A., Mokhova, E. N., Vyssokikh, M. Y., Pustovidko, A. V., Markova, O. V., Yaguzhinsky, L. S., Korshunova, G. A., Sumbatyan, N. V., Skulachev, M. V., and Skulachev, V. P. (2010. Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore, Proc. Natl. Acad. Sci. USA, 107, 663–668.PubMedCentralCrossRefPubMedGoogle Scholar
  10. 10.
    Skulachev, M. V., Antonenko, Y. N., Anisimov, V. N., Chernyak, B. V., Cherepanov, D. A., Chistyakov, V. A., Egorov, M. V., Kolosova, N. G., Korshunova, G. A., Lyamzaev, K. G., Plotnikov, E. Y., Roginsky, V. A., Savchenko, A. Y., Severina, I. I., Severin, F. F., Shkurat, T. P., Tashlitsky, V. N., Shidlovsky, K. M., Vyssokikh, M. Y., Zamyatnin, A. A., Jr., Zorov, D. B., and Skulachev, V. P. (2011. Mitochondria-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies, Curr. Drug Targets, 12, 800–826.CrossRefPubMedGoogle Scholar
  11. 11.
    Neroev, V. V., Archipova, M. M., Bakeeva, L. E., Fursova, A. Zh., Grigoryan, E. N., Grishanova, A. Yu., Iomdina, E. N., Ivashchenko, Zh. N., Katargina, L. A., KhoroshilovaMaslova, I. P., Kilina, O. V., Kolosova, N. G., Kopenkin, E. P., Korshunov, S. S., Kovaleva, N. A., Novikova, Yu. P., Filippov, P. P., Pilipenko, D. I., Robustova, O. V., Saprunova, V. B., Senin, I. I., Skulachev, M. V., Sotnikova, L. F., Stefanova, N. A., Tikhomirova, N. K., Tsapenko, I. V., Shchipanova, A. I., Zinovkin, R. A., and Skulachev, V. P. (2008. Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 4. Age-related eye disease. SkQ1 returns vision to blind animals, Biochemistry (Moscow), 73, 13171328.CrossRefGoogle Scholar
  12. 12.
    Yani, Ye. V., Katargina, L. A., Chesnokova, N. B., Beznos, O. V., Savchenko, A. Yu., Vygodin, Ye. Yu., Gudkova, Ye. Yu., Zamyatnin, A. A., Jr., and Skulachev, M. V. (2012. The first experience of using Visomitin in “dry eye” treatment, Prakt. Med., 1, 134–137.Google Scholar
  13. 13.
    Myasoedova, K. N., and Silachev, D. N. (2014. Therapeutic doses of SkQ1 do not induce cytochromes P450 in rat liver, Biochemistry (Moscow), 79, 1130–1132.CrossRefGoogle Scholar
  14. 14.
    Omura, T., and Sato, R. (1964. Carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature, J. Biol. Chem., 239, 2370–2378.PubMedGoogle Scholar
  15. 15.
    Dawson, R., Elliott, D., and Jones, K. (1991) Directory of a Biochemist [Russian translation], Mir, Moscow.Google Scholar

Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.Lomonosov Moscow State UniversityFaculty of Fundamental MedicineMoscowRussia
  2. 2.Lomonosov Moscow State UniversityInstitute of MitoengineeringMoscowRussia
  3. 3.Lomonosov Moscow State UniversityBelozersky Institute of Physico-Chemical BiologyMoscowRussia

Personalised recommendations