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Biochemistry (Moscow)

, Volume 80, Issue 12, pp 1571–1577 | Cite as

DNA methylation, mitochondria, and programmed aging

  • L. A. Zinovkina
  • R. A. ZinovkinEmail author
Mini-Review

Abstract

DNA methylation is a key epigenetic process involved in the regulation of nuclear gene expression. Progress in the study of genomic DNA methylation led to the precise identification of methylation sites reflecting biological age of cells and tissues. However, the functional significance of mitochondrial DNA (mtDNA) methylation remains unknown. Growing evidence suggests that mtDNA methylation is linked to aging and oxidative stress. This mini-review summarizes information about the methylation of nuclear and mtDNA in mammals, indicating the connection of these processes to programmed aging.

Keywords

epigenetics DNA methylation mitochondria aging 

Abbreviations

DNMT

DNA-methyltransferase

5hmC

5-hydroxymethylcytosine

5mC

5-methylcytosine

mtDNA

mitochondrial DNA

mtROS

mitochondrial reactive oxygen species

nDNA

nuclear DNA

TET

ten-eleven-translocation oxygenase

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Copyright information

© Pleiades Publishing, Ltd. 2015

Authors and Affiliations

  1. 1.Lomonosov Moscow State UniversityFaculty of Bioengineering and BioinformaticsMoscowRussia
  2. 2.Belozersky Institute of Physico-Chemical BiologyLomonosov Moscow State UniversityMoscowRussia

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